The oral route is by far the most common route of drug administration in the gastrointestinal
tract and can be used for both systemic drug delivery and for treating local gastrointestinal …

Conventional drug administrations are associated with low bioavailability, high cost, more
side effects, uncontrolled release profile, and patient noncompliance. Therefore, the …

Purpose. Although oral delivery has become a widely accepted route of administration of
therapeutic drugs, the gastrointestinal tract presents several formidable barriers to drug …

The purpose of this study was to design novel colon specific drug delivery system containing
flurbiprofen (FLB) microsponges. Microsponges containing FLB and Eudragit RS 100 were …

In case of colon-specific delivery of therapeutic agents through oral route, microbial/enzyme-
triggered release approach has several advantages over other approaches due to unique …

Targeting drugs and delivery systems to the colonic region of the gastrointestinal tract has
received considerable interest in recent years. Scientific endeavour in this area has been …

In conscious and co‐operating patients, oral drug delivery remains the preferable route of
drug administration. However, not all drugs possess the desirable physicochemical and …

Injection Molding (IM) consists in the injection, under high pressure conditions, of heat-
induced softened materials into a mold cavity where they are shaped. The advantages the …

The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core
surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able …

The delivery of macromolecules via the gastrointestinal (GI) tract remains a significant
challenge. A variety of technologies using physical modes of drug delivery have been …