Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

Histone ubiquitylation is a critical part of both active and repressed transcriptional states,
and lies at the heart of DNA damage repair signaling. The histone residues targeted for …

The chemical synthesis of homogeneously modified histones is a powerful approach to
quantitatively decipher how post-translational modifications (PTMs) modulate epigenetic …

Heterochromatin assembly, involving histone H3 lysine-9 methylation (H3K9me), is
nucleated at specific genomic sites but can self-propagate across extended domains and …

Mechanisms enabling genetically identical cells to differentially regulate gene expression
are complex and central to organismal development and evolution. While gene silencing …

Heterochromatin is a gene-repressive protein–nucleic acid ultrastructure that is initially
nucleated by DNA sequences. However, following nucleation, heterochromatin can then …

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-
stage renal disease, and is characterized by persistent proteinuria and decreased …

Mechanisms regulating neurogenesis involve broad and complex processes that represent
intriguing therapeutic targets in the field of regenerative medicine. One influential factor …

Mono-ubiquitination of lysine 18 on histone H3 (H3K18ub), catalyzed by UHRF1, is a
DNMT1 docking site that facilitates replication-coupled DNA methylation maintenance. Its …

The establishment and maintenance of heterochromatin, a specific chromatin structure
essential for genomic stability and regulation, rely on intricate interactions between …