Development of antibiofilm therapeutics strategies to overcome antimicrobial drug resistance

S Nadar, T Khan, SG Patching, A Omri - Microorganisms, 2022 - mdpi.com
A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix
produced by themselves. Many types of microorganisms that are found on living hosts or in …

Cyclodextrin: A prospective nanocarrier for the delivery of antibacterial agents against bacteria that are resistant to antibiotics

P Saha, MR Rafe - Heliyon, 2023 - cell.com
Supramolecular chemistry introduces us to the macrocyclic host cyclodextrin, which has a
hydrophobic cavity. The hydrophobic cavity has a higher affinity for hydrophobic guest …

Potential antimicrobial and antibiofilm efficacy of essential oil nanoemulsion loaded polycaprolactone nanofibrous dermal patches

ME El-Naggar, AM Abdelgawad, R Abdel-Sattar… - European Polymer …, 2023 - Elsevier
Formulating nanofibers loaded with active compounds for biomedical purposes has recently
drawn great attention. In this work, polycaprolactone (PCL) was blended with peppermint oil …

Chromobacterium violaceum: a model for evaluating the anti-quorum sensing activities of plant substances

PD Dimitrova, T Damyanova… - Scientia …, 2023 - mdpi.com
In the new antibiotic era, the exponential increase in multiresistant bacterial strains has
become the main global health problem. Many researchers have focused their efforts on …

Hybrid Chitosan/CaO-Based Nanocomposites Doped with Plant Extracts from Azadirachta indica and Melia azedarach: Evaluation of Antibacterial and Antibiofilm …

T Paunova-Krasteva, BA Hemdan, PD Dimitrova… - Bionanoscience, 2023 - Springer
This study examines substances from plant leaves of Azadirachta indica and Melia
azedarach extracted with methanol (80%) and then successively fractionated with …

An overview of biofilm-associated infections and the role of phytochemicals and nanomaterials in their control and prevention

T Damyanova, PD Dimitrova, D Borisova… - Pharmaceutics, 2024 - mdpi.com
Biofilm formation is considered one of the primary virulence mechanisms in Gram-positive
and Gram-negative pathogenic species, particularly those responsible for chronic infections …

Bulgarian medicinal extracts as natural inhibitors with antiviral and antibacterial activity

I Nikolova, T Paunova-Krasteva, Z Petrova… - Plants, 2022 - mdpi.com
Background: Bulgaria is a country with a wide range of medicinal plants, with uses in
traditional medicine dating back for centuries. Methods: Disc diffusion assay was used to …

Mupirocin at Subinhibitory Concentrations Induces Biofilm Formation in Staphylococcus aureus

R Sritharadol, M Hamada, S Kimura, Y Ishii… - Microbial Drug …, 2018 - liebertpub.com
Objectives: Mupirocin is a useful antibiotic against superficial skin infections. We compared
the impact of mupirocin with a cephalosporin, a fluoroquinolone, an aminoglycoside, and a …

Effects of biotic and abiotic factors on biofilm growth dynamics and their heterogeneous response to antibiotic challenge

L Machineni - Journal of biosciences, 2020 - Springer
Over the last couple of decades, with the crisis of new antimicrobial arsenal, multidrug-
resistant clinical pathogens have been observed extensively. In clinical and medical …

The concept for the antivirulence therapeutics approach as alternative to antibiotics: hope or still a fiction?

S Stoitsova, T Paunova-Krasteva… - Biotechnology & …, 2022 - Taylor & Francis
While the development of antibiotics since their first discovery brought about a revolutionary
step forward in the fight against infectious microorganisms, unfortunately its side effect was …