Antimalarial drug resistance in Africa: the calm before the storm?
MD Conrad, PJ Rosenthal - The Lancet Infectious Diseases, 2019 - thelancet.com
Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …
the treatment and control of malaria. In this Review, we summarise evolving patterns of …
Emerging implications of policies on malaria treatment: genetic changes in the Pfmdr-1 gene affecting susceptibility to artemether–lumefantrine and artesunate …
LC Okell, LM Reiter, LS Ebbe, V Baraka, D Bisanzio… - BMJ global …, 2018 - gh.bmj.com
Artemether–lumefantrine (AL) and artesunate–amodiaquine (AS-AQ) are the most
commonly used artemisinin-based combination therapies (ACT) for treatment of …
commonly used artemisinin-based combination therapies (ACT) for treatment of …
Polymorphisms in K13 and Falcipain-2 Associated with Artemisinin Resistance Are Not Prevalent in Plasmodium falciparum Isolated from Ugandan Children
The emergence of resistance to artemisinin derivatives in Southeast Asia, manifested as
delayed clearance of Plasmodium falciparum following treatment with artemisinins, is a …
delayed clearance of Plasmodium falciparum following treatment with artemisinins, is a …
Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study
Background Treatment and control of malaria depends on artemisinin-based combination
therapies (ACTs) and is challenged by drug resistance, but thus far resistance to …
therapies (ACTs) and is challenged by drug resistance, but thus far resistance to …
Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT
Polymorphisms in the Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene
and the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene alter the …
and the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene alter the …
Comparative Impacts Over 5 Years of Artemisinin-Based Combination Therapies on Plasmodium falciparum Polymorphisms That Modulate Drug Sensitivity in …
MD Conrad, N LeClair, E Arinaitwe… - The Journal of …, 2014 - academic.oup.com
Background. Artemisinin-based combination therapies, including artemether-lumefantrine
(AL) and dihydroartemisinin-piperaquine (DP), are recommended to treat uncomplicated …
(AL) and dihydroartemisinin-piperaquine (DP), are recommended to treat uncomplicated …
Role of Pfmdr1 in In Vitro Plasmodium falciparum Susceptibility to Chloroquine, Quinine, Monodesethylamodiaquine, Mefloquine, Lumefantrine, and …
N Wurtz, B Fall, A Pascual, M Fall, E Baret… - Antimicrobial agents …, 2014 - Am Soc Microbiol
ABSTRACT The involvement of Pfmdr1 (Plasmodium falciparum multidrug resistance 1)
polymorphisms in antimalarial drug resistance is still debated. Here, we evaluate the …
polymorphisms in antimalarial drug resistance is still debated. Here, we evaluate the …
Changing antimalarial drug sensitivities in Uganda
SA Rasmussen, FG Ceja, MD Conrad… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Dihydroartemisinin-piperaquine (DP) has demonstrated excellent efficacy for the treatment
and prevention of malaria in Uganda. However, resistance to both components of this …
and prevention of malaria in Uganda. However, resistance to both components of this …
Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs
Abstract Background Dihydroartemisinin-piperaquine (DHA-PPQ) is an alternative first-line
antimalarial to artemether-lumefantrine in Kenya. However, recent reports on the emergence …
antimalarial to artemether-lumefantrine in Kenya. However, recent reports on the emergence …
pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies
Introduction: Plasmodium falciparum, the deadly agent of malaria, is notorious for its
capacity to develop drug resistance. Treatment failures of artemisinin therapy regimens …
capacity to develop drug resistance. Treatment failures of artemisinin therapy regimens …