Cell surface glycosylation has a variety of functions, and its dysregulation in cancer
contributes to impaired signaling, metastasis and the evasion of the immune responses …

High-grade serous carcinoma (HGSC) is the most prevalent and aggressive subtype of
ovarian cancer. The large degree of clinical heterogeneity within HGSC has justified …

Purpose: Ewing sarcoma is the second most common bone sarcoma in children, with 1 case
per 1.5 million in the United States. Although the survival rate of patients diagnosed with …

Accidental injury to the cardiac conduction system (CCS), a network of specialized cells
embedded within the heart and indistinguishable from the surrounding heart muscle tissue …

Urine is a complex biofluid that reflects both overall physiologic state and the state of the
genitourinary tissues through which it passes. It contains both secreted proteins and proteins …

Synovial fluid (SF) extracellular vesicles (EVs) play a pathogenic role in osteoarthritis (OA).
However, the surface markers, cell and tissue origins, and effectors of these EVs are largely …

Cancer immunotherapies produce remarkable results in B cell malignancies; however,
optimal cell surface targets for many solid cancers remain elusive. Here, we present an …

The SH-SY5Y neuroblastoma cells are a widely used in vitro model approximating neurons
for testing the target engagement of therapeutics designed for neurodegenerative diseases …

The collection of exposed plasma membrane proteins, collectively termed the surfaceome, is
involved in multiple vital cellular processes, such as the communication of cells with their …

Cardiac cell surface proteins are drug targets and useful biomarkers for discriminating
among cellular phenotypes and disease states. Here we developed an analytical platform …