Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling

S Bossi, L Pizzamiglio, P Paoletti - Trends in Neurosciences, 2023 - cell.com
GluN3A is a glycine-binding subunit belonging to the NMDA receptor (NMDAR) family that
can assemble with GluN1 subunits to form unconventional NMDARs insensitive to glutamate …

How to distinguish seizures from non‐epileptic manifestations

A Leibetseder, M Eisermann… - Epileptic …, 2020 - Wiley Online Library
The first and most important step in establishing diagnosis of epilepsy consists of careful
history taking from patients and witnesses. The clinical evaluation of the event will lead the …

The Concise Guide to PHARMACOLOGY 2013/14: ion channels

SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

The impact of human hyperekplexia mutations on glycine receptor structure and function

A Bode, JW Lynch - Molecular brain, 2014 - Springer
Hyperekplexia is a rare neurological disorder characterized by neonatal hypertonia,
exaggerated startle responses to unexpected stimuli and a variable incidence of apnoea …

Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses

SA Maynard, P Rostaing, N Schaefer, O Gemin… - Elife, 2021 - elifesciences.org
Precise quantitative information about the molecular architecture of synapses is essential to
understanding the functional specificity and downstream signaling processes at specific …

Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs

A Kumar, K Kindig, S Rao, AM Zaki, S Basak… - Nature …, 2022 - nature.com
Nociception and motor coordination are critically governed by glycine receptor (GlyR)
function at inhibitory synapses. Consequentially, GlyRs are attractive targets in the …

GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic …

J Deckert, H Weber, C Villmann, TB Lonsdorf… - Molecular …, 2017 - nature.com
The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still
largely unknown and progress is hampered by small sample sizes. We therefore performed …

Glycine receptor subtypes and their roles in nociception and chronic pain

VP San Martín, A Sazo, E Utreras… - Frontiers in molecular …, 2022 - frontiersin.org
Disruption of the inhibitory control provided by the glycinergic system is one of the major
mechanisms underlying chronic pain. In line with this concept, recent studies have provided …

[HTML][HTML] The mRNA expression profile of glycine receptor subunits alpha 1, alpha 2, alpha 4 and beta in female and male mice

MM Ceder, KA Magnusson, HM Weman… - Molecular and Cellular …, 2024 - Elsevier
Glycine receptors are ligand-gated chloride-selective channels that control excitability in the
central nervous system (CNS). Herein, we have investigated the mRNA expression of the …

Gephyrin and the regulation of synaptic strength and dynamics at glycinergic inhibitory synapses

FJ Alvarez - Brain research bulletin, 2017 - Elsevier
Glycinergic synapses predominate in brainstem and spinal cord where they modulate motor
and sensory processing. Their postsynaptic mechanisms have been considered rather …