The immunopathology of sepsis: pathogen recognition, systemic inflammation, the compensatory anti‐inflammatory response, and regulatory T cells

DH Lewis, DL Chan, D Pinheiro… - Journal of Veterinary …, 2012 - Wiley Online Library
Sepsis, the systemic inflammatory response to infection, represents the major cause of death
in critically ill veterinary patients. Whereas important advances in our understanding of the …

Immune regulation of procalcitonin: a biomarker and mediator of infection

GN Matwiyoff, JD Prahl, RJ Miller, JJ Carmichael… - Inflammation …, 2012 - Springer
Procalcitonin (PCT) has recently emerged as a powerful biomarker for an early and accurate
diagnosis of bacterial infection. Here we summarize our current understanding of the …

Serial analysis of blood biomarker concentrations in dogs with pneumonia, septic peritonitis, and pyometra

R Goggs, SN Robbins… - Journal of Veterinary …, 2022 - Wiley Online Library
Background Prolonged antimicrobial drug (AMD) treatment is associated with antimicrobial
resistance development. Biomarker measurement may aid treatment decision‐making …

Plasma procalcitonin concentrations predict organ dysfunction and outcome in dogs with sepsis

R Troia, M Giunti, R Goggs - BMC veterinary research, 2018 - Springer
Background Procalcitonin (PCT) is a valuable prognostic biomarker in human sepsis that is
predictive of organ dysfunction, septic shock and mortality. Data on PCT in dogs is limited …

Plasma procalcitonin concentration in healthy calves and those with septic systemic inflammatory response syndrome

F Bonelli, V Meucci, TJ Divers, A Boccardo… - The Veterinary …, 2018 - Elsevier
The diagnosis of sepsis in calves is challenging. Blood culture and clinical signs combined
with a complete blood count have been used for the diagnosis of sepsis. Recent literature in …

Plasma procalcitonin concentration in healthy horses and horses affected by systemic inflammatory response syndrome

F Bonelli, V Meucci, TJ Divers… - Journal of veterinary …, 2015 - Wiley Online Library
Background The diseases most frequent associated with SIRS in adult horses are those
involving the gastrointestinal tract. An early diagnosis should be the goal in the management …

Plasma inflammatory mediator concentrations at ICU admission in dogs with naturally developing sepsis

AE DeClue, CR Sharp… - Journal of veterinary …, 2012 - Wiley Online Library
Background Identifying biomarkers to aide in the diagnosis and prognostication of sepsis in
dogs would be valuable to veterinarians. Objective To compare plasma inflammatory …

Procalcitonin: present and future

HH Liu, JB Guo, Y Geng, L Su - Irish Journal of Medical Science (1971-), 2015 - Springer
Critically ill patients are frequently at risk of sepsis or inflammatory conditions. Procalcitonin
(PCT) is a biomarker for critically ill patients to differentiate sepsis from non-infectious …

Plasma procalcitonin concentrations are increased in dogs with sepsis

R Goggs, M Milloway, R Troia… - Veterinary record open, 2018 - Wiley Online Library
Sepsis, the life‐threatening organ dysfunction caused by a dysregulated host response to
infection, is difficult to identify and to prognosticate for. In people with sepsis, procalcitonin …

Serum procalcitonin concentrations in dogs with induced endotoxemia

F Easley, MK Holowaychuk… - Journal of veterinary …, 2020 - Wiley Online Library
Background Procalcitonin (PCT) is an important biomarker for sepsis in human medicine,
but there is little information regarding PCT as a biomarker for sepsis in dogs. There are no …