Amino acids are attractive and promising biochemicals with market capacity requirements
constantly increasing. Their applicability ranges from animal feed additives, flavour …

The combination of synthetic and systems biology is a powerful framework to study
fundamental questions in biology and produce chemicals of immediate practical application …

Gradients in industrial bioreactors have attracted substantial research attention since
exposure to fluctuating environmental conditions has been shown to lead to changes in the …

Escherichia coli fed-batch cultivations at 22 m3 scale were compared to corresponding
laboratory scale processes and cultivations using a scale-down reactor furnished with a high …

The presence of spatial gradients in fundamental culture parameters, such as dissolved
gases, pH, concentration of substrates, and shear rate, among others, is an important …

To increase product yields and to ensure consistent product quality, key issues of industrial
fermentations, process optimization and scale up are aimed at maintaining optimum and …

Anaerobic microbial fermentations provide high product yields and are a cornerstone of
industrial bio-based processes. However, the need for redox balancing limits the array of …

Industrial biotechnological production is developing rapidly worldwide. Consequently, more
and novel bioprocesses need to perform optimally not only in small lab-but also in large …

Bioprocess scale‐up is a fundamental component of process development in the
biotechnology industry. When scaling up a mammalian cell culture process, it is important to …

Mixing phenomena are regarded as one of the major factors responsible for the failure to
successfully scale up some bioprocesses. Such phenomena have been investigated within …