WNT/β-catenin signaling is involved in many physiological processes. Its implication in
embryonic development, cell migration, and polarization has been shown. Nevertheless …

Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals
provided by the local hippocampal microenvironment support neural stem cell proliferation …

Abstract WNT family member 4 (WNT4), which belongs to the conserved WNT protein family,
plays an important role in the development and differentiation of many cell types during the …

To ensure dosage compensation between the sexes, one randomly chosen X chromosome
is silenced in each female cell in the process of X-chromosome inactivation (XCI). XCI is …

RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling.
We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling …

High grade serous carcinoma of the ovary, fallopian tube, and peritoneum (HGSC) is the
deadliest gynecological disease which results in a five-year survival rate of 30% or less …

In adult hippocampal neurogenesis, stem/progenitor cells generate dentate granule neurons
that contribute to hippocampal plasticity. The establishment of a morphologically defined …

Limbal stem cell deficiency and corneal disorders are among the top global threats for
human vision. Emerging therapies that integrate stem cell transplantation with engineered …

The Wnt pathway is involved in several processes essential for bone development and
homeostasis. For proper functioning, the Wnt pathway is tightly regulated by numerous …

The choroid plexus (ChP) produces cerebrospinal fluid and forms an essential brain barrier.
ChP tissues form in each brain ventricle, each one adopting a distinct shape, but remarkably …