Role of chemokine systems in cancer and inflammatory diseases

H Li, M Wu, X Zhao - MedComm, 2022 - Wiley Online Library
Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

[HTML][HTML] The relationship between chronic immune response and neurodegenerative damage in long COVID-19

JP Elizalde-Díaz, CL Miranda-Narváez… - Frontiers in …, 2022 - frontiersin.org
In the past two years, the world has faced the pandemic caused by the severe acute
respiratory syndrome 2 coronavirus (SARS-CoV-2), which by August of 2022 has infected …

[HTML][HTML] Burn-injured skin is marked by a prolonged local acute inflammatory response of innate immune cells and pro-inflammatory cytokines

PPG Mulder, M Vlig, E Fasse, MM Stoop… - Frontiers in …, 2022 - frontiersin.org
The systemic and local immune response in burn patients is often extreme and derailed. As
excessive inflammation can damage healthy tissues and slow down the healing process …

The efficacy of fecal microbiota transplantation in experimental autoimmune encephalomyelitis: transcriptome and gut microbiota profiling

S Wang, H Chen, X Wen, J Mu, M Sun… - Journal of …, 2021 - Wiley Online Library
Objective. To study the protective effect of fecal microbiota transplantation (FMT) on
experimental autoimmune encephalomyelitis (EAE) and reveal its potential intestinal …

CCL17/TARC in autoimmunity and inflammation—not just a T‐cell chemokine

TJ Lupancu, M Eivazitork, JA Hamilton… - … and Cell Biology, 2023 - Wiley Online Library
Abstract Chemokine (C–C) ligand 17 (CCL17) was first identified as thymus‐and activation‐
regulated chemokine when it was found to be constitutively expressed in the thymus and …

[HTML][HTML] Targeting the CCL2-CCR2 axis in depressive disorders

K Curzytek, M Leśkiewicz - Pharmacological Reports, 2021 - Springer
Since affective disorders are considered to be underlain by the immune system malfunction,
an important role in their pathophysiology is assigned to the proinflammatory mediators …

Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation

E Pajarillo, I Nyarko‐Danquah, A Digman, C Vied… - Glia, 2023 - Wiley Online Library
Abstract The transcription factor Yin Yang 1 (YY1) is ubiquitously expressed in mammalian
cells, regulating the expression of a variety of genes involved in proliferation, differentiation …

Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion of mesenchymal stem cells in multiple sclerosis patients

G Hassanshahi, MA Roohi, SA Esmaeili… - Cytokine, 2021 - Elsevier
Multiple sclerosis (MS) is a specific type of chronic immune-mediated disease in which the
immune responses are almost run against the central nervous system (CNS). Despite …

[HTML][HTML] Nesfatin-1 stimulates CCL2-dependent monocyte migration and M1 macrophage polarization: implications for rheumatoid arthritis therapy

JW Chang, SC Liu, YY Lin, XY He, YS Wu… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Rheumatoid arthritis (RA) is a prototypic inflammatory disease, characterized by the
infiltration of proinflammatory cytokines into the joint synovium and the migration of …

[HTML][HTML] CC chemokine receptor 4 (CCR4) as a possible new target for therapy

J Bogacka, K Pawlik, K Ciapała… - International Journal of …, 2022 - mdpi.com
Chemokines and their receptors participate in many biological processes, including the
modulation of neuroimmune interactions. Approximately fifty chemokines are distinguished …