Epstein–Barr virus and multiple sclerosis

SS Soldan, PM Lieberman - Nature Reviews Microbiology, 2023 - nature.com
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Epstein–Barr virus as a leading cause of multiple sclerosis: mechanisms and implications

K Bjornevik, C Münz, JI Cohen, A Ascherio - Nature Reviews Neurology, 2023 - nature.com
Epidemiological studies have provided compelling evidence that multiple sclerosis (MS) is a
rare complication of infection with the Epstein–Barr virus (EBV), a herpesvirus that infects …

Primary epstein-barr virus infection

SK Dunmire, PS Verghese, HH Balfour Jr - Journal of Clinical Virology, 2018 - Elsevier
Epstein-Barr virus (EBV) infects about 90% of adults worldwide. It is the main cause of
infectious mononucleosis, which is observed most frequently in adolescents. The disease …

Humanized mouse models of clinical disease

NC Walsh, LL Kenney, S Jangalwe… - Annual Review of …, 2017 - annualreviews.org
Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized
mice, have become increasingly important as small, preclinical animal models for the study …

IL‐10: a multifunctional cytokine in viral infections

JM Rojas, M Avia, V Martín… - Journal of immunology …, 2017 - Wiley Online Library
The anti‐inflammatory master regulator IL‐10 is critical to protect the host from tissue
damage during acute phases of immune responses. This regulatory mechanism, central to T …

The immunology of Epstein-Barr virus–induced disease

GS Taylor, HM Long, JM Brooks… - Annual review of …, 2015 - annualreviews.org
Epstein-Barr virus (EBV) is usually acquired silently early in life and carried thereafter as an
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …

Natural killer cells in myeloid malignancies: immune surveillance, NK cell dysfunction, and pharmacological opportunities to bolster the endogenous NK cells

M Carlsten, M Järås - Frontiers in immunology, 2019 - frontiersin.org
Natural killer (NK) cells are large granular lymphocytes involved in our defense against
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …

EBV-associated diseases: Current therapeutics and emerging technologies

S Chakravorty, B Afzali, M Kazemian - Frontiers in Immunology, 2022 - frontiersin.org
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …

Human immunity against EBV—lessons from the clinic

SG Tangye, U Palendira, ESJ Edwards - Journal of Experimental …, 2017 - rupress.org
The mammalian immune system has evolved over many millennia to be best equipped to
protect the host from pathogen infection. In many cases, host and pathogen have coevolved …

Recognition and regulation of T cells by NK cells

K Pallmer, A Oxenius - Frontiers in immunology, 2016 - frontiersin.org
Regulation of T cell responses by innate lymphoid cells (ILCs) is increasingly documented
and studied. Direct or indirect crosstalk between ILCs and T cells early during and after T …