Antibody‐incorporated nanomedicines for cancer therapy

SY Wu, FG Wu, X Chen - Advanced Materials, 2022 - Wiley Online Library
Antibody‐based cancer therapy, one of the most significant therapeutic strategies, has
achieved considerable success and progress over the past decades. Nevertheless …

Radiochemistry with {Al18F} 2+: Current status and optimization perspectives for efficient radiofluorination by complexation

S Schmitt, E Moreau - Coordination Chemistry Reviews, 2023 - Elsevier
With the aim to efficiently develop and synthesize new radiotracers for PET imaging, and
their use for theranostic approaches, radiolabeling technics have not ceased to progress …

Protein engineering strategies for improved pharmacokinetics

A Rondon, S Mahri, F Morales‐Yanez… - Advanced Functional …, 2021 - Wiley Online Library
Protein therapeutics have gained momentum in recent years and become a pillar in treating
many diseases and the only choice in several ailments. Protein therapeutics are highly …

Click chemistry and targeted degradation: a winning combination for medicinal chemists?

A Pasieka, E Diamanti, E Uliassi… - …, 2023 - Wiley Online Library
Click chemistry is universally recognized as a powerful strategy for the fast and precise
assembly of diverse building blocks. Targeted Protein Degradation (TPD) is a new …

[HTML][HTML] Perspectives on metals-based radioimmunotherapy (RIT): moving forward

JM White, FE Escorcia, NT Viola - Theranostics, 2021 - ncbi.nlm.nih.gov
Radioimmunotherapy (RIT) is FDA-approved for the clinical management of liquid
malignancies, however, its use for solid malignancies remains a challenge. The putative …

Tetrazine bioorthogonal chemistry makes nanotechnology a powerful toolbox for biological applications

R Zhang, J Gao, G Zhao, L Zhou, F Kong, T Jiang… - Nanoscale, 2023 - pubs.rsc.org
Bioorthogonal chemistry enables researchers to manipulate bioactive molecules in living
systems. These highly selective and biocompatible reactions can be carried out in various …

1, 2, 4, 5-Tetrazine derivatives as components and precursors of photo-and electroactive materials

GN Lipunova, EV Nosova, GV Zyryanov… - Organic Chemistry …, 2021 - pubs.rsc.org
Extensive research on the synthesis and application of tetrazine derivatives for electronic
devices, luminescent elements, photoelectric conversion elements, and image sensors has …

[68 Ga] Ga-THP-tetrazine for bioorthogonal click radiolabelling: pretargeted PET imaging of liposomal nanomedicines

A Mishra, A Carrascal-Miniño, J Kim… - RSC Chemical …, 2024 - pubs.rsc.org
Pretargeted PET imaging using bioorthogonal chemistry is a leading strategy for the tracking
of long-circulating agents such as antibodies and nanoparticle-drug delivery systems with …

Exploration of novel linker scaffolds enabling the simultaneous rebridging of disulfide bonds for the synthesis of antibody-drug conjugates

T King - 2023 - repository.cam.ac.uk
Antibody-drug conjugates (ADCs) are a class of targeted therapeutic, typically used for the
treatment of cancers. By attaching drugs site-selectively to antibodies, off-target toxicity of the …

Isolation of Hepatocellular carcinoma (HCC) derived extracellular vesicles Using click-chemistry conjugated immunomagnetic beads

S Mentink - 2023 - essay.utwente.nl
Hepatocellular carcinoma (HCC) is one of the top five most common malignant tumour types
in the western world. The asymptomatic nature of early stage HCC leads to an issue that …