Phase I clinical trials have shown that pure human butyrylcholinesterase (BChE) is safe
when administered to humans. A potential therapeutic use of BChE is for prevention of nerve …

The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …

By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates
neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme …

Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the
hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase has unique …

Abstract The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying
the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain …

The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic
synapses by rapidly hydrolysing acetylcholine. It is anchored within the synaptic cleft by a …

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol
(Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid …

Objective Endophenotype studies of obsessive-compulsive disorder (OCD) may uncover
heritable traits that are related to genetic susceptibility to OCD. Deficient response inhibition …

A common feature in the Alzheimer's disease (AD) brain is the presence of
acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and …

Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …