Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as
microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers …

DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-
frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within …

Mutations in codons 12 and 13 of the KRAS oncogene are relatively common in colorectal
and lung adenocarcinomas. Recent data indicate that these mutations result in resistance to …

Purpose We investigated in the first-line setting our previous finding that patients with
chemorefractory KRAS G13D–mutated metastatic colorectal cancer (mCRC) benefit from …

Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes.
MMR deficiency has long been regarded as a secondary event in the pathogenesis of Lynch …

Background & Aims: The concept of a CpG island methylator phenotype (CIMP), especially
in microsatellite stable colon cancer, is not accepted universally. We therefore evaluated a …

Background: KRAS mutation is a negative predictive factor for treatment with anti-epidermal
growth factor receptor antibody in metastatic colorectal cancer (CRC). KRAS mutation …

Colorectal cancer is a serious health problem, a challenge for research, and a model for
studying the molecular mechanisms involved in its development. According to its incidence …

A wide variety of tumours show PIK3CA mutations leading to increased phosphatidylinositol-
3 kinase (PI3K) activity. We have determined the frequency of PIK3CA mutations in exons 9 …

Abstract Background KRAS and BRAF V600E mutations are important predictive and
prognostic markers, respectively, in colon cancer, but little is known about patient and …