Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup

A Zarbock, MK Nadim, P Pickkers, H Gomez… - Nature Reviews …, 2023 - nature.com
Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill patients and is
strongly associated with adverse outcomes, including an increased risk of chronic kidney …

COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

MK Nadim, LG Forni, RL Mehta, MJ Connor Jr… - Nature reviews …, 2020 - nature.com
Kidney involvement in patients with coronavirus disease 2019 (COVID-19) is common, and
can range from the presence of proteinuria and haematuria to acute kidney injury (AKI) …

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

L Evans, A Rhodes, W Alhazzani, M Antonelli… - Critical care …, 2021 - journals.lww.com
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

[HTML][HTML] Oxygen-saturation targets for critically ill adults receiving mechanical ventilation

MW Semler, JD Casey, BD Lloyd… - … England Journal of …, 2022 - Mass Medical Soc
Background Invasive mechanical ventilation in critically ill adults involves adjusting the
fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation …

Balanced multielectrolyte solution versus saline in critically ill adults

S Finfer, S Micallef, N Hammond… - … England Journal of …, 2022 - Mass Medical Soc
Background Whether the use of balanced multielectrolyte solution (BMES) in preference to
0.9% sodium chloride solution (saline) in critically ill patients reduces the risk of acute kidney …

[HTML][HTML] Endoscopic diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH): European Society of Gastrointestinal Endoscopy …

IM Gralnek, AJ Stanley, AJ Morris, M Camus, J Lau… - …, 2021 - thieme-connect.com
1 ESGE recommends in patients with acute upper gastrointestinal hemorrhage (UGIH) the
use of the Glasgow–Blatchford Score (GBS) for pre-endoscopy risk stratification. Patients …

Lactate activates the mitochondrial electron transport chain independently of its metabolism

X Cai, CP Ng, O Jones, TS Fung, KW Ryu, D Li… - Molecular cell, 2023 - cell.com
Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

SL Weiss, MJ Peters, W Alhazzani, MSD Agus… - Intensive care …, 2020 - Springer
Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Effect of intravenous fluid treatment with a balanced solution vs 0.9% saline solution on mortality in critically ill patients: the BaSICS randomized clinical trial

FG Zampieri, FR Machado, RS Biondi, FGR Freitas… - Jama, 2021 - jamanetwork.com
Importance Intravenous fluids are used for almost all intensive care unit (ICU) patients.
Clinical and laboratory studies have questioned whether specific fluid types result in …

[HTML][HTML] Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment

S Peerapornratana, CL Manrique-Caballero… - Kidney international, 2019 - Elsevier
Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill
patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is …