SN Palacios-Rápalo, LA De Jesus-Gonzalez… - Frontiers in …, 2021 - frontiersin.org
Since its appearance, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), the causal agent of Coronavirus Disease 2019 (COVID-19), represents a global problem for …
Y Zhu, F Feng, G Hu, Y Wang, Y Yu, Y Zhu… - Nature …, 2021 - nature.com
The global spread of SARS-CoV-2 is posing major public health challenges. One feature of SARS-CoV-2 spike protein is the insertion of multi-basic residues at the S1/S2 subunit …
H Wang, JA Kulas, C Wang… - Proceedings of the …, 2021 - National Acad Sciences
Alzheimer's disease (AD) is characterized by the presence of amyloid β (Aβ) plaques, tau tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol …
Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or pathogen, such as virus or bacteria, but its association with diminished cholesterol levels in …
F Chen, Y Chen, Y Wang, Q Ke, L Cui - Translational neurodegeneration, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease, especially …
WYT Tan, BE Young, DC Lye, DEK Chew, R Dalan - Scientific reports, 2020 - nature.com
We aim to study the association of hyperlipidemia and statin use with COVID-19 severity. We analysed a retrospective cohort of 717 patients admitted to a tertiary centre in Singapore for …
I Ripa, S Andreu, JA López-Guerrero… - Frontiers in …, 2021 - frontiersin.org
Membrane rafts are dynamic, small (10–200 nm) domains enriched with cholesterol and sphingolipids that compartmentalize cellular processes. Rafts participate in roles essential to …
DK Shoemark, CK Colenso, C Toelzer… - Angewandte …, 2021 - Wiley Online Library
We investigate binding of linoleate and other potential ligands to the recently discovered fatty acid binding site in the SARS‐CoV‐2 spike protein, using docking and molecular …
COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis. Predisposing …