The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …

DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are
covalently crosslinked to the DNA by the action of variety of agents like reactive oxygen …

MRE11, the core of the MRE11/RAD50/NBS1 complex, is one of key DNA damage response
proteins. Increasing evidence suggests that its expression in cancer cells is critical to …

Background External radiation therapy (RT) is often a primary treatment for inoperable
meningiomas in the absence of established chemotherapy. Histone deacetylase 6 (HDAC6) …

The ATPase p97 is a central component of the ubiquitin-proteasome degradation system.
p97 uses its ATPase activity and co-factors to extract ubiquitinated substrates from different …

Simple Summary Defects in MRE11A/RAD50/NBS1 (MRN) genes and overexpression of the
MRN proteins are both linked to cancer, generating confusion about how the MRN complex …

DNA-protein cross-links (DPCs) are generated by internal factors such as cellular aldehydes
that are generated during normal metabolism and external factors such as environmental …

Many cancer therapy strategies cause DNA damage leading to the death of tumor cells. The
DNA damage response (DDR) modulators are considered as promising candidates for use …

Abstract Objective Head and Neck Squamous Cell Carcinoma (HNSCC) ranks as the sixth
most prevalent form of cancer worldwide. MRE11 protein contains multiple domains that …

Objectives To analyze the correlations between the expression and effect of DNA damage
repair genes and the immune status and clinical outcomes of urothelial bladder cancer …