Topoisomerases are essential enzymes that solve topological problems arising from the
double-helical structure of DNA. As a consequence, one should have naively expected to …

High-fidelity chromosomal DNA replication is fundamental to all forms of cellular life and
requires the complex interplay of a wide variety of essential and non-essential protein …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

The archaeal machinery responsible for DNA replication is largely homologous to that of
eukaryotes and is clearly distinct from its bacterial counterpart. Moreover, it shows high …

DNA gyrase is a type II topoisomerase with the unique capacity to introduce negative
supercoiling in DNA. In bacteria, DNA gyrase has an essential role in the homeostatic …

Recent advances in the characterization of the archaeal DNA replication system together
with comparative genomic analysis have led to the identification of several previously …

Three evolutionarily distinct families of replicative DNA polymerases, designated
polymerase B (Pol B), Pol C, and Pol D, have been identified. Members of the Pol B family …

Deinococcaceae are a family of extremely radiation-tolerant bacteria that are currently
subjected to numerous studies aimed at understanding the molecular mechanisms for such …

DNA replication is essential for all life forms. Although the process is fundamentally
conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic …

Genes encoding DNA replication proteins have been frequently exchanged between cells
and mobile elements, such as viruses or plasmids. This raises potential problems to …