Asymmetric organocatalysis has proven to be one of the most versatile methods for the
enantioselective α-functionalisation of aldehydes. Initially pioneered by the report of an L …

As the programs for computer-aided retrosynthetic design come of age, they are no longer
identifying just one or few synthetic routes but a multitude of chemically plausible syntheses …

A direct vinylogous Michael reaction of γ-substituted deconjugated butenolides with
nitroolefins has been developed with the help of a newly identified quinine-derived …

A gold‐catalyzed asymmetric cyclopropanation of unactivated olefins with sulfonium ylides
in the presence of a bimetallic catalyst with a novel dimeric TADDOL‐phosphoramidite …

Herein the preparative (1 g scale), stereoselective syntheses of various alkyl‐substituted γ‐
butyrolactone fragrances 1 is described. The α, β‐unsaturated γ‐keto esters 2 as starting …

Since Sharpless' discovery of the asymmetric dihydroxylation of C= C double bonds in the
late 1980s this reaction has become a powerful tool of synthetic organic chemistry. As a …

An efficient asymmetric synthesis of trans-4, 5-disubstituted γ-butyrolactones from aldehydes
and enantioenriched γ-carbamate alkenylboronates is reported. The cornerstone of this …

An operationally simple protocol for the synthesis of γ-hydroxy vinyl sulfones has been
developed using a proline-based aldehyde aminooxylation, followed by a vinyl sulfone …

Selenium reagents are useful for selenoenzyme-mimicking reactions, as well as for organic
synthesis. However, the reaction waste containing selenium frequently smells unpleasant …

A new enantioselective synthesis of two important fungal metabolites,(+)-stagonolide C and
(−)-aspinolide A, has been described from readily available raw materials. Proline catalyzed …