The American Diabetes Association, JDRF, the European Association for the Study of
Diabetes, and the American Association of Clinical Endocrinologists convened a research …

Glucose metabolism is normally regulated by a feedback loop including islet β cells and
insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell …

Aims/hypothesis The aim of this study was to assess the risk of adverse perinatal outcomes
in gestational diabetes mellitus (GDM) in a large national cohort. Methods All deliveries …

Hypertension is a major risk factor for cardiovascular disease and mortality. To identify
targets for the prevention of hypertension and its associated disease burden, we used the 2 …

Importance In observational studies, abdominal adiposity has been associated with type 2
diabetes and coronary heart disease (CHD). Whether these associations represent causal …

Background: Global dietary recommendations for and cardiovascular effects of linoleic acid,
the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain …

Objectives To identify the genetic determinants of fracture risk and assess the role of 15
clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide …

Objective To determine which potentially modifiable risk factors, including socioeconomic,
lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's …

We give critical attention to the assumptions underlying Mendelian randomization analysis
and their biological plausibility. Several scenarios violating the Mendelian randomization …

Genetic variation can modulate gene expression, and thereby phenotypic variation and
susceptibility to complex diseases such as type 2 diabetes (T2D). Here we harnessed the …