Accelerating antibody discovery and design with artificial intelligence: Recent advances and prospects

G Bai, C Sun, Z Guo, Y Wang, X Zeng, Y Su… - Seminars in Cancer …, 2023 - Elsevier
Therapeutic antibodies are the largest class of biotherapeutics and have been successful in
treating human diseases. However, the design and discovery of antibody drugs remains …

Replacement in angiogenesis research: Studying mechanisms of blood vessel development by animal-free in vitro, in vivo and in silico approaches

MW Laschke, Y Gu, MD Menger - Frontiers in physiology, 2022 - frontiersin.org
Angiogenesis, the development of new blood vessels from pre-existing ones, is an essential
process determining numerous physiological and pathological conditions. Accordingly …

Convection-enhanced delivery of antiangiogenic drugs and liposomal cytotoxic drugs to heterogeneous brain tumor for combination therapy

A Bhandari, K Jaiswal, A Singh, W Zhan - Cancers, 2022 - mdpi.com
Simple Summary Although developed anticancer drugs have shown desirable effects in
preclinical trials, the clinical efficacy of chemotherapy against brain cancer remains …

Comparative analysis of machine learning and numerical modeling for combined heat transfer in Polymethylmethacrylate

M Dehghan Manshadi, N Alafchi, A Tat, M Mousavi… - Polymers, 2022 - mdpi.com
This study has compared different methods to predict the simultaneous effects of conductive
and radiative heat transfer in a polymethylmethacrylate (PMMA) sample. PMMA is a type of …

Automated quantification of crack length and width in asphalt pavements

Z Li, T Zhang, Y Miao, J Zhang… - … ‐Aided Civil and …, 2024 - Wiley Online Library
Rapid, accurate, and fully automated estimation of both length and width of asphalt
pavement cracks, essential for achieving a proactive asset management, presents a …

Numerical simulation and mathematical modeling of biomechanical stress distribution in poroelastic tumor tissue via magnetic field and bio-ferro-fluid

M Halabian, B Beigzadeh, M Siavashi - Heliyon, 2024 - cell.com
Based on scientific evidence, it seems that bio-magnetic systems can change the process of
cancer cell death by affecting the distribution of pressure and mechanical stress in the tumor …

An Asynchronous Spiking Neural Membrane System for Edge Detection.

L Zhang, F Xu, F Neri - International journal of neural systems, 2024 - europepmc.org
Spiking neural membrane systems (SN P systems) are a class of bio-inspired models
inspired by the activities and connectivity of neurons. Extensive studies have been made on …

Multi-dimensional modeling of nanoparticles transportation from capillary bed into the tumor microenvironment

S Jafari-Matanagh, SE Razavi, MBE Bonab… - Computers in Biology …, 2023 - Elsevier
In this study, we examined the extravasation of pharmaceutical inorganic nanoparticles
(NPs) with a new approach from the leaky endothelium of tumor microvasculature (TMV) into …

Optimizing the therapeutic window of sirolimus by monitoring blood concentration for the treatment of immune thrombocytopenia

Y Zhang, Y Quan, D Wang, K Cassady, W Zou, J Xiong… - Platelets, 2023 - Taylor & Francis
Previous studies have demonstrated that sirolimus (SRL) is an effective agent for the
treatment of refractory/relapsed (R/R) ITP. However, the therapeutic window of sirolimus in …

Robust Federated Learning for Heterogeneous Model and Data.

HA Madni, RM Umer, GL Foresti - International Journal of Neural …, 2024 - europepmc.org
Data privacy and security is an essential challenge in medical clinical settings, where
individual hospital has its own sensitive patients data. Due to recent advances in …