Highlights•This review re-explores the comparison between phenotypic and target-based
drug discovery and outlines how machine learning (ML) can assist the former at the forefront …

Nucleic acids represent a major class of pathogen and damage signatures, recognized by a
variety of host sensors to initiate signaling cascades and immune responses, such as …

Drugging large protein pockets is a challenge due to the need for higher molecular weight
ligands, which generally possess undesirable physicochemical properties. In this …

Chemogenetic libraries, collections of well-defined chemical probes, provide tremendous
value to biomedical research but require substantial effort to ensure diversity as well as …

Here, we explore the manipulation of immune cell metabolism as a strategy in target
discovery and drug development for immune-mediated diseases. Comparing exploitation of …

Myeloid derived macrophages play a key role in many human diseases, and their
therapeutic modulation via pharmacological means is receiving considerable attention. Of …

The activation of stimulator of interferon genes (STING) signaling pathways plays an
important role in the innate immune response. Although several STING agonists have been …

Biologically active small molecules have a central role in drug development, and as
chemical probes and tool compounds to perturb and elucidate biological processes. Small …

Photodynamic therapy (PDT) is an emerging anti-tumor strategy. Photosensitizer chlorin e6
(Ce6) can induce photodynamic effect to selectively damage lung cancer cells. In order to …

The cyclic dinucleotide-cGAS–STING axis plays important roles in host immunity. Activation
of this signaling pathway, via cytosolic sensing of bacterial-derived c-di-GMP/c-di-AMP or …