Effective intraocular drug delivery poses a major challenge due to the presence of various
elimination mechanisms and physiological barriers that result in low ocular bioavailability …

Ultrasound is a unique and exciting theranostic modality that can be used to track drug
carriers, trigger drug release and improve drug deposition with high spatial precision. In this …

Interest in stimuli-responsive polymers has persisted over many decades, and a great deal
of work has been dedicated to developing environmentally sensitive macromolecules that …

Amphiphilic block copolymers (ABCs) have been used extensively in pharmaceutical
applications ranging from sustained-release technologies to gene delivery. The utility of …

Block copolymer micelles are generally formed by self-assembly of amphiphilic copolymer
molecules in an aqueous milieu. The hydrophobic blocks (or polyion complexes) form the …

Ultrasound has an ever-increasing role in the delivery of therapeutic agents, including
genetic material, protein and chemotherapeutic agents. Cavitating gas bodies, such as …

The low solubility in biological fluids displayed by about 50% of the drugs still remains the
main limitation in oral, parenteral, and transdermal administration. Among the existing …

Background Drug delivery in polymeric micelles combined with tumor irradiation by
ultrasound results in effective drug targeting, but this technique requires prior tumor imaging …

Doxorubicin (DOX) is one of the most commonly used chemotherapeutic drugs and is a
popular research tool due to the inherent fluorescence of the DOX molecule. After DOX …

Drug delivery research employing micelles and nanoparticles has expanded in recent years.
Of particular interest is the use of these nanovehicles that deliver high concentrations of …