Limited understanding of human proteoforms with complex posttranslational modifications
and the underlying mechanisms poses a major obstacle to research on human health and …

Mirror-image proteins and peptides composed of D-amino acids are garnering increasing
attention as diagnostic agents and drug candidates due to their higher stability and lower …

Chemical ligation of peptides is increasingly used to generate proteins not readily
accessible by recombinant approaches. However, a robust method to ligate “difficult” …

Synthetic α-galactosylceramide (αGalCer) and its analogues as powerful agonists for natural
killer T (NKT) cell manipulation have received significant attention in immunotherapy and …

Abiotic d-proteins that selectively bind to natural l-proteins have gained significant
biotechnological interest. However, the underlying structural principles governing such …

Protein-based subunit vaccines are weakly immunogenic, and developing self-adjuvanting
vaccines with adjuvant conjugated to antigen is a promising approach for generating optimal …

The DNA damage repair regulatory protein RNF168, a monomeric RING-type E3 ligase, has
a crucial role in regulating cell fate and DNA repair by specific and efficient ubiquitination of …

The glycosylation of peptides and proteins can significantly impact their intrinsic properties,
such as conformation, stability, antigenicity, and immunogenicity. Current methods for …

The chemical synthesis of histones with homogeneous modifications is a powerful approach
for quantitatively deciphering the functional crosstalk between different post‐translational …

We report the development of a novel synthetic approach for the highly strained atrop‐Tyr C‐
6‐to‐Trp N‐1′ linkage, which can be executed on a decagram scale using a modular …