Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

Cell proliferation and differentiation show a remarkable inverse relationship. Precursor cells
continue division before acquiring a fully differentiated state, while terminal differentiation …

The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …

Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities
are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Close cooperation …

Pluripotent stem cells (PSCs) retain the ability to differentiate into a wide range of cell types
while undergoing self-renewal. They also exhibit an unusual mode of cell cycle regulation …

Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

The identification of neurological symptoms caused by vitamin A deficiency pointed to a
critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The …

Direct neuronal reprogramming is a promising approach to regenerate neurons from local
glial cells. However, mechanisms of epigenome remodeling and co-factors facilitating this …