Digital twins and automation of care in the intensive care unit

J Geoffrey Chase, C Zhou, JL Knopp… - Cyber–Physical …, 2023 - Wiley Online Library
Healthcare is under increasing demand pressure as societies age and expectations rise,
multiplied by increasing incidence of chronic diseases and decreasing available funding …

Digital twins in critical care: what, when, how, where, why?

JG Chase, C Zhou, JL Knopp, GM Shaw, K Näswall… - IFAC-PapersOnLine, 2021 - Elsevier
Healthcare and intensive care unit (ICU) medicine in particular, are facing a devastating
tsunami of rising demand multiplied by increasing chronic disease and aging demographics …

Context aware control systems: An engineering applications perspective

RAC Diaz, M Ghita, D Copot, IR Birs, C Muresan… - IEEE …, 2020 - ieeexplore.ieee.org
Cyber-physical systems revolve around context awareness, empowering objective-oriented
services, products and operations based on real data. Self-aware and self-control systems …

Model based care in the ICU: A review of potential combined cardio-pulmonary models

J Cushway, L Murphy, JG Chase, G Shaw, T Desaive… - Plos one, 2024 - journals.plos.org
Positive end-expiratory pressure results in a sustained positive intrathoracic pressure, which
exerts pressure on intrathoracic vessels, resulting in cardiopulmonary interactions. This …

Estimation of cardiac stroke volume from radial pulse waveform by artificial neural network

H Xiao, D Liu, AP Avolio, K Chen, D Li, B Hu… - Computer Methods and …, 2022 - Elsevier
Abstract Background and Objectives: Stroke volume (SV) and cardiac output (CO) are the
key indicators for the evaluation of cardiac function and hemodynamic status during the …

Physiological trend analysis of a novel cardio-pulmonary model during a preload reduction manoeuvre

J Cushway, L Murphy, JG Chase, GM Shaw… - Computer Methods and …, 2022 - Elsevier
Background and objective: Mechanical ventilation causes adverse effects on the
cardiovascular system. However, the exact nature of the effects on haemodynamic …

Modelling patient specific cardiopulmonary interactions

J Cushway, L Murphy, JG Chase, GM Shaw… - Computers in Biology …, 2022 - Elsevier
Mechanical ventilation is well known for having detrimental effects on the cardiovascular
system, particularly when using high positive end-expiratory pressure. High positive end …

Single measurement estimation of central blood pressure using an arterial transfer function

L Murphy, JG Chase - Computer Methods and Programs in Biomedicine, 2023 - Elsevier
Background: Central blood pressure (BP) better reflects the loading conditions on the major
organs and is more closely correlated with future cardiovascular events. The increased …

Preload & Frank-Starling curves, from textbook to bedside: Clinically applicable non-additionally invasive model-based estimation in pigs

R Smith, JG Chase, CG Pretty, S Davidson… - Computers in Biology …, 2021 - Elsevier
Background Determining physiological mechanisms leading to circulatory failure can be
challenging, contributing to the difficulties in delivering effective hemodynamic management …

Tube-load model: A clinically applicable pulse contour analysis method for estimation of cardiac stroke volume

R Smith, L Murphy, CG Pretty, T Desaive… - Computer Methods and …, 2021 - Elsevier
Abstract Background and Objectives: Accurate, reproducible, and reliable real-time clinical
measurement of stroke volume (SV) is challenging. To accurately estimate arterial …