The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …

Enormous studies have corroborated that long non-coding RNAs (lncRNAs) extensively
participate in crucial physiological processes such as metabolism and immunity, and are …

Chronic pulmonary diseases encompass different persistent and lethal diseases, including
chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic …

Abstract Design of experiment (DoE) is a powerful statistical technique used for variable
screening and optimization. It is based on the simultaneous variation of multiple factors with …

Therapeutic biologics such as genes, peptides, proteins, virus and cells provide clinical
benefits and are becoming increasingly important tools in respiratory medicine. Pulmonary …

Oxidative stress is significantly involved in the pathogenesis and progression of chronic
obstructive pulmonary disease (COPD). Combining antioxidant drugs or nutrients results in …

Introduction During past years, lipid nanoparticles (LNPs) have emerged as promising
carriers for RNA delivery, with several clinical trials focusing on both infectious diseases and …

Thermostable dry powder inhaler (DPI) formulations with high aerosol performance are
attractive inhalable solid dosage forms for local treatment of inflammatory lung diseases. We …

Lung diseases are a leading cause of mortality worldwide and there exists urgent need for
new therapies. Approval of the first siRNA treatments in humans has opened the door for …

Some issues in pharmaceutical therapies such as instability, poor membrane permeability,
and bioavailability of drugs can be solved by the design of suitable delivery systems based …