The term thiazide is universally understood to refer to diuretics that exert their principal
action in the distal tubule. The thiazide class is heterogenous and can be further subdivided …

Despite evidence-based interventions, coronary heart disease (CHD) remains a leading
cause of global mortality. As therapies advance, patient non-adherence to established …

Objective The objective is to formulate clinical practice guidelines for the treatment of
diabetes in older adults. Conclusions Diabetes, particularly type 2, is becoming more …

Objectives This study compared combination diuretic strategies in acute heart failure (AHF)
complicated by diuretic resistance (DR). Background Combination diuretic regimens to …

The sodium–chloride cotransporter (NCC) is critical for kidney physiology. The NCC has a
major role in salt reabsorption in the distal convoluted tubule of the nephron,, and mutations …

The management of sodium intake is clinically important in many disease states including
heart failure, kidney disease, and hypertension. Tenapanor is an inhibitor of the sodium …

Objective: To compare two drug regimens to treat resistant hypertension. Methods: In a
prospective, randomized, open blinded endpoint study, 167 patients with mean baseline …

Thiazide diuretics are widely used for the management of hypertension. In recent years, it
has been actively debated that there is interchangeability of thiazide‐type diuretics …

Hypertension is a significant and costly public health problem. It is a major, but modifiable
contributor for the development of cardiovascular disease. Randomized controlled trials …

Objective: To present a cogent and practical review of the medical complications and their
treatment in patients with bulimia nervosa. Method: Thorough review of the medical literature …