Liver cancer: molecular characterization, clonal evolution and cancer stem cells
G Castelli, E Pelosi, U Testa - Cancers, 2017 - mdpi.com
Liver cancer is the second most common cause of cancer-related death. The major forms of
primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic …
primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic …
A framework for fibrolamellar carcinoma research and clinical trials
Fibrolamellar carcinoma (FLC), a rare, lethal hepatic cancer, occurs primarily in adolescents
and young adults. Unlike hepatocellular carcinoma, FLC has no known association with …
and young adults. Unlike hepatocellular carcinoma, FLC has no known association with …
[HTML][HTML] Phase separation of a PKA regulatory subunit controls cAMP compartmentation and oncogenic signaling
The fidelity of intracellular signaling hinges on the organization of dynamic activity
architectures. Spatial compartmentation was first proposed over 30 years ago to explain how …
architectures. Spatial compartmentation was first proposed over 30 years ago to explain how …
Driver fusions and their implications in the development and treatment of human cancers
Q Gao, WW Liang, SM Foltz, G Mutharasu… - Cell reports, 2018 - cell.com
Gene fusions represent an important class of somatic alterations in cancer. We
systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple …
systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple …
[HTML][HTML] Recurrent rearrangements in PRKACA and PRKACB in intraductal oncocytic papillary neoplasms of the pancreas and bile duct
Background & Aims Intraductal oncocytic papillary neoplasms (IOPNs) of the pancreas and
bile duct contain epithelial cells with numerous, large mitochondria and are cystic precursors …
bile duct contain epithelial cells with numerous, large mitochondria and are cystic precursors …
Sex-specific role for the long non-coding RNA LINC00473 in depression
Depression is a common disorder that affects women at twice the rate of men. Here, we
report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory …
report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory …
The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma
The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar
hepatocellular carcinoma, a lethal disease lacking specific therapies. This study reports on …
hepatocellular carcinoma, a lethal disease lacking specific therapies. This study reports on …
DNAJB1–PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma
ER Kastenhuber, G Lalazar… - Proceedings of the …, 2017 - National Acad Sciences
A segmental deletion resulting in DNAJB1–PRKACA gene fusion is now recognized as the
signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal …
signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal …
ChimerDB 4.0: an updated and expanded database of fusion genes
Fusion genes represent an important class of biomarkers and therapeutic targets in cancer.
ChimerDB is a comprehensive database of fusion genes encompassing analysis of deep …
ChimerDB is a comprehensive database of fusion genes encompassing analysis of deep …
[HTML][HTML] CRISPR/Cas9 engineering of adult mouse liver demonstrates that the Dnajb1–Prkaca gene fusion is sufficient to induce tumors resembling fibrolamellar …
LH Engelholm, A Riaz, D Serra, F Dagnæs-Hansen… - Gastroenterology, 2017 - Elsevier
Background & Aims Fibrolamellar hepatocellular carcinoma (FL-HCC) is a primary liver
cancer that predominantly affects children and young adults with no underlying liver …
cancer that predominantly affects children and young adults with no underlying liver …