Artificial intelligence and data mining for the pharmacovigilance of drug–drug interactions

M Hauben - Clinical Therapeutics, 2023 - Elsevier
Despite increasing mechanistic understanding, undetected and underrecognized drug–drug
interactions (DDIs) persist. This elusiveness relates to an interwoven complexity of …

[HTML][HTML] Signal detection in pharmacovigilance: a review of informatics-driven approaches for the discovery of drug-drug interaction signals in different data sources

H Ibrahim, A Abdo, AM El Kerdawy, AS Eldin - Artificial intelligence in the …, 2021 - Elsevier
The objective of this article is to review the application of informatics-driven approaches in
the pharmacovigilance field with focus on drug-drug interaction (DDI) safety signal discovery …

DDI-GCN: drug-drug interaction prediction via explainable graph convolutional networks

Y Zhong, H Zheng, X Chen, Y Zhao, T Gao… - Artificial Intelligence in …, 2023 - Elsevier
Drug-drug interactions (DDI) may lead to unexpected side effects, which is a growing
concern in both academia and industry. Many DDIs have been reported, but the underlying …

CPInformer for efficient and robust compound-protein interaction prediction

Y Hua, X Song, Z Feng, XJ Wu… - … /ACM transactions on …, 2022 - ieeexplore.ieee.org
Recently, deep learning has become the mainstream methodology for Compound-Protein
Interaction (CPI) prediction. However, the existing compound-protein feature extraction …

[HTML][HTML] Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature

AA Supianto, R Nurdiansyah, CW Weng… - Journal of Taibah …, 2023 - Elsevier
Objective The coronavirus disease 2019 (COVID-19) health crisis that began at the end of
2019 made researchers around the world quickly race to find effective solutions. Related …

Prediction of drug-target interactions by ensemble learning method from protein sequence and drug fingerprint

X Zhan, ZH You, J Cai, L Li, C Yu, J Pan, J Kong - IEEE Access, 2020 - ieeexplore.ieee.org
Predicting the target-drug interactions (DITs) is of great important for screening new drug
candidate and understanding biological processes. However, identifying the drug-target …

A Rule‐Based Inference Framework to Explore and Explain the Biological Related Mechanisms of Potential Drug‐Drug Interactions

A Noor, A Assiri - Computational and Mathematical Methods in …, 2022 - Wiley Online Library
As more drugs are developed and the incidence of polypharmacy increases, it is becoming
critically important to anticipate potential DDIs before they occur in the clinic, along with …

Integrating mechanistic information to predict drug-drug interactions and associated relevance for decision support

A Noor - 2022 IEEE International IOT, Electronics and …, 2022 - ieeexplore.ieee.org
While computational methods offer great potential in predicting drug-drug interactions
(DDIs), such predictions as of yet have limited utility in supporting clinical decision-making; …

[HTML][HTML] Estimating the optimal dexketoprofen pharmaceutical formulation with machine learning methods and statistical approaches

A Başkor, YP Tok, B Mesut, Y Özsoy… - Healthcare Informatics …, 2021 - ncbi.nlm.nih.gov
Objectives Orally disintegrating tablets (ODTs) can be utilized without any drinking water;
this feature makes ODTs easy to use and suitable for specific groups of patients. Oral …

Towards DDIs Identification by Knowledge Graph with BiRW and Back Aggregation

Z Yin, X Lin, X Zhang - 2022 IEEE International Conference on …, 2022 - ieeexplore.ieee.org
Effective identification of potential drug-drug interactions (DDIs) can prevent adverse effects
caused by DDIs to a certain extent. This paper proposes the new hybrid method for …