[HTML][HTML] Mammalian SWI/SNF chromatin remodeling complexes: emerging mechanisms and therapeutic strategies
RC Centore, GJ Sandoval, LMM Soares, C Kadoch… - Trends in Genetics, 2020 - cell.com
Small molecule-based targeting of chromatin regulatory factors has emerged as a promising
therapeutic strategy in recent years. The development and ongoing clinical evaluation of …
therapeutic strategy in recent years. The development and ongoing clinical evaluation of …
[HTML][HTML] Cellular and molecular mechanisms underlying prostate cancer development: therapeutic implications
U Testa, G Castelli, E Pelosi - Medicines, 2019 - mdpi.com
Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
[HTML][HTML] Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin
remodelling and is altered in over 20% of cancers,. Here we developed a proteolysis …
remodelling and is altered in over 20% of cancers,. Here we developed a proteolysis …
[HTML][HTML] A disordered region controls cBAF activity via condensation and partner recruitment
Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear
protein content. The prevailing dogma is that IDRs engage in non-specific interactions …
protein content. The prevailing dogma is that IDRs engage in non-specific interactions …
[HTML][HTML] A structural model of the endogenous human BAF complex informs disease mechanisms
Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling complexes that
regulate genomic architecture. Here, we present a structural model of the endogenously …
regulate genomic architecture. Here, we present a structural model of the endogenously …
[HTML][HTML] Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
Acquired resistance to tyrosine kinase inhibitors (TKI), such as osimertinib used to treat
EGFR-mutant lung adenocarcinomas, limits long-term efficacy and is frequently caused by …
EGFR-mutant lung adenocarcinomas, limits long-term efficacy and is frequently caused by …
A pioneer factor locally opens compacted chromatin to enable targeted ATP-dependent nucleosome remodeling
MA Frederick, KE Williamson… - Nature structural & …, 2023 - nature.com
To determine how different pioneer transcription factors form a targeted, accessible
nucleosome within compacted chromatin and collaborate with an ATP-dependent chromatin …
nucleosome within compacted chromatin and collaborate with an ATP-dependent chromatin …
ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer
Mutations in ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, are the most
common alterations of the SWI/SNF complex in estrogen-receptor-positive (ER+) breast …
common alterations of the SWI/SNF complex in estrogen-receptor-positive (ER+) breast …
[HTML][HTML] In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis
D Lara-Astiaso, A Goñi-Salaverri, J Mendieta-Esteban… - Nature …, 2023 - nature.com
Cellular differentiation requires extensive alterations in chromatin structure and function,
which is elicited by the coordinated action of chromatin and transcription factors. By contrast …
which is elicited by the coordinated action of chromatin and transcription factors. By contrast …
Peptide SMIM30 promotes HCC development by inducing SRC/YES1 membrane anchoring and MAPK pathway activation
Background & Aims Growing evidence shows that some non-coding RNAs (ncRNAs)
contain small open reading frames (smORFs) that are translated into short peptides. Herein …
contain small open reading frames (smORFs) that are translated into short peptides. Herein …