The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

The cysteine protease legumain (also known as asparaginyl endopeptidase or δ-secretase)
is the only known mammalian asparaginyl endopeptidase and is primarily localized to the …

Fluorouracil (5-FU) has been commonly used as a chemotherapy medication in cancer
management. However, owing to its substantial side effects, limited selectivity, and tumor …

Whereas protease inhibitors have been developed successfully against hypertension and
viral infections, they have failed thus far as cancer drugs. With advances in cancer profiling …

Alzheimer's disease (AD) is incurable dementia closely associated with aging. Most cases of
AD are sporadic, and very few are inherited; the pathogenesis of sporadic AD is complex …

Background: Recent reports indicate that the tumor microenvironment plays a pivotal role in
cancer development and progression, leading to a paradigm shift in the way cancer is …

Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-
target cell. However, diverse colchicine analogs have been derivatized as intentions for …

Legumain, which is also known as vacuolar processing enzyme (VPE) or asparaginyl
endopeptidase (AEP), is a cysteine protease that was first discovered and characterized in …

Proteases play essential roles in protein degradation, protein processing, and extracellular
matrix remodeling in all cell types and tissues. They are also involved in protein turnover for …

Polymer-directed enzyme prodrug therapy (PDEPT) and polymer enzyme liposome therapy
(PELT) are two-step therapies developed to provide anticancer drugs site-selective …