Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

A considerable body of evidence has accumulated over recent years on the functions of the
default-mode network (DMN)–a set of brain regions whose activity is high when the mind is …

Importance Severe neuropsychiatric conditions, such as schizophrenia, affect distributed
neural computations. One candidate system profoundly altered in chronic schizophrenia …

Recent findings suggest the existence of a frontoparietal control system consisting of flexible
hubs that regulate distributed systems (eg, visual, limbic, motor) according to current task …

N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …

Schizophrenia is a devastating neuropsychiatric syndrome associated with distributed brain
dysconnectivity that may involve large-scale thalamo-cortical systems. Incomplete …

This review describes unique neuromodulatory influences on working memory prefrontal
cortical (PFC) circuits that coordinate cognitive strength with arousal state. Working memory …

Neurons in the primate dorsolateral prefrontal cortex (dlPFC) generate persistent firing in the
absence of sensory stimulation, the foundation of mental representation. Persistent firing …

Traditional antidepressants require many weeks to reveal their therapeutic effects. However,
the widely replicated observation that a single subanesthetic dose of the N-methyl-D …

NMDA receptors mediate excitatory postsynaptic potentials throughout the brain but,
paradoxically, NMDA receptor antagonists produce cortical excitation in humans and …