[HTML][HTML] Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming
Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …
since their discovery. However, their use in therapy has been complicated by severe side …
[HTML][HTML] The role of p53 in cancer drug resistance and targeted chemotherapy
K Hientz, A Mohr, D Bhakta-Guha, T Efferth - Oncotarget, 2017 - ncbi.nlm.nih.gov
Cancer has long been a grievous disease complicated by innumerable players aggravating
its cure. Many clinical studies demonstrated the prognostic relevance of the tumor …
its cure. Many clinical studies demonstrated the prognostic relevance of the tumor …
Organic cation transporters in health and disease
H Koepsell - Pharmacological reviews, 2020 - ASPET
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
Mechanisms of multidrug resistance in cancer
JP Gillet, MM Gottesman - Multi-drug resistance in cancer, 2010 - Springer
The development of multidrug resistance (MDR) to chemotherapy remains a major
challenge in the treatment of cancer. Resistance exists against every effective anticancer …
challenge in the treatment of cancer. Resistance exists against every effective anticancer …
The SLC22 family with transporters of organic cations, anions and zwitterions
H Koepsell - Molecular aspects of medicine, 2013 - Elsevier
The SLC22 family contains 13 functionally characterized human plasma membrane proteins
each with 12 predicted α-helical transmembrane domains. The family comprises organic …
each with 12 predicted α-helical transmembrane domains. The family comprises organic …
Renal drug transporters and drug interactions
Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy
AT Nies, H Koepsell, K Damme, M Schwab - Drug transporters, 2011 - Springer
Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 and multidrug and
toxin extrusion (MATE) transporters of the SLC47 family have been identified as uptake and …
toxin extrusion (MATE) transporters of the SLC47 family have been identified as uptake and …
The role of transporters in the pharmacokinetics of orally administered drugs
S Shugarts, LZ Benet - Pharmaceutical research, 2009 - Springer
Drug transporters are recognized as key players in the processes of drug absorption,
distribution, metabolism, and elimination. The localization of uptake and efflux transporters …
distribution, metabolism, and elimination. The localization of uptake and efflux transporters …
[HTML][HTML] Drug uptake-based chemoresistance in breast cancer treatment
H Muley, R Fado, R Rodriguez-Rodriguez… - Biochemical …, 2020 - Elsevier
Breast cancer is the most prevalent type of tumor and the second leading cause of death
due to cancer among women. Although screening methods, diagnosis and therapeutic …
due to cancer among women. Although screening methods, diagnosis and therapeutic …
The expression and function of organic anion transporting polypeptides in normal tissues and in cancer
A Obaidat, M Roth, B Hagenbuch - Annual review of …, 2012 - annualreviews.org
Organic anion transporting polypeptides (OATPs) are members of the SLCO gene
superfamily of proteins. The 11 human OATPs are classified into 6 families and subfamilies …
superfamily of proteins. The 11 human OATPs are classified into 6 families and subfamilies …