Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Flavonoids are naturally occurring bioactive phytochemical metabolites widely known to
prevent and suppress several human diseases, and are important sources of therapeutic …

Introduction Donepezil (DPL), a specific acetylcholinesterase inhibitor, is used as a first-line
treatment to improve cognitive deficits in Alzheimer's disease (AD) and it might have a …

Donepezil hydrochloride is an acetylcholine esterase inhibitor studied and approved to treat
Alzheimer's disease (AD). However, this drug can have positive therapeutic potential in …

One of the primary therapeutic approaches for managing Alzheimer's disease (AD) involves
the modulation of Acetylcholine esterase (AChE) activity to elevate acetylcholine (ACh) …

Alzheimer's disease is a type of cerebrovascular problem with progressive mental
disabilities for the patient. This study aimed to investigate the protective effect of safranal on …

Alzheimer's disease is the commonest form of dementia associated with short-term memory
loss and impaired cognition and, worldwide, it is a growing health issue. A number of …

Objectives The study has been commenced to discover the potential of Phlorizin (dual SGLT
inhibitor) in streptozotocin induced dementia of Alzheimer's disease (AD) type. Material and …

Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for
treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that pervasively
affects the population across the world. Currently, there is no effective treatment available for …