The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

Inflammation is involved in tumor development and progression as well as antitumor
response to therapy. In the past decade, the crosstalk between inflammation, immunity, and …

As a key component of the inflammasome, NLRP3 is a critical intracellular danger sensor
emerging as an important clinical target in inflammatory diseases. However, little is known …

Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As
the underlying mechanisms of this inflammation remain poorly defined, specific therapies …

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the world.
Inflammation is often an underlying risk factor for developing CRC. Maintaining gut …

Cytosolic NOD-like receptors (NLRs) have been associated with human diseases including
infections, cancer, and autoimmune and inflammatory disorders. These innate immune …

Primary progressive multiple sclerosis is a poorly understood disease entity with no specific
prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity …

Objective To evaluate genetic, demographic and clinical features in patients with cryopyrin-
associated periodic syndrome (CAPS) from the Eurofever Registry, with a focus on genotype …

Accumulating data indicates that following anti-cancer treatments, cancer cell death can be
perceived as immunogenic or tolerogenic by the immune system. The former is made …

NOD-like receptors (NLRs) are intracellular sensors associated with systemic
autoinflammatory diseases (SAIDs). We investigated the largest monocentric cohort of …