Our understanding of the biology of pain is limited by our ignorance about its evolution. We
know little about how states in other species showing various degrees of apparent similarity …

Chronic pain afflicts as much as 50% of the population at any given time but our methods to
address pain remain limited, ineffective and addictive. In order to develop new therapies an …

In mammals, pain is regulated by the combination of an ascending stimulating and
descending inhibitory pain pathway. It remains an intriguing question whether such pain …

Nociception and pain sensation are important neural processes in humans to avoid injury.
Many proteins are involved in nociception and pain sensation in humans; however, the …

Voltage gated calcium channels (VGCCs) regulate neuronal excitability and translate activity
into calcium dependent signaling. The α1 subunit of high voltage activated (HVA) VGCCs …

Background: Several evolutionary explanations have been proposed for why chronic pain is
a major clinical problem. One is that some mechanisms important for driving chronic pain …

Chronic pain has an enormous impact on the quality of life of billions of patients, families,
and caregivers worldwide. Current therapies do not adequately address pain for most …

Objective. The purpose of the present study (a randomized clinical trial) was to evaluate the
preemptive analgesic effects of pregabalin combined with celecoxib in total knee …

Postoperative fatigue is prevalent, but non-small cell lung cancer (NSCLC) patients receive
poor treatment after video-assisted thoracoscopic surgery (VATS). The main objective of the …

Objectives: Vitamin B complexes are frequently used in clinical practice for peripheral nerve
trauma. However, there is a lack of scientific data on their effectiveness. This study aims to …