The ability of cells to respond to changes in nutrient availability is essential for the
maintenance of metabolic homeostasis and viability. One of the key cellular responses to …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Abstract Members of the Transient Receptor Potential-Mucolipin (TRPML) constitute a family
of evolutionarily conserved cation channels that function predominantly in endolysosomal …

Blockade of lysosomal calcium release due to lysosomal lipid accumulation has been
shown to inhibit mTORC1 signaling. However, the mechanism by which lysosomal calcium …

Cytokines and chemokines are produced and secreted by a broad range of immune cells
including macrophages. Remarkably, little is known about how these inflammatory …

Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of
which is lysosomal degradation and subsequent recycling of cytoplasmic material to …

Autophagy, the process of cellular self-degradation, is intrinsically tied to the degradative
function of the lysosome. Several diseases have been linked to lysosomal degradative …

Abstract The old Greek saying “Panta Rhei”(“everything flows”) is true for all life and all living
things in general. It also becomes nicely evident when looking closely into cells. There …

What do lysosomal storage disorders such as mucolipidosis type IV have in common with
Ebola, cancer cell migration, or LDL-cholesterol trafficking? LDL-cholesterol, certain …

Autophagy is a complex pathway regulated by numerous signalling events that recycles
macromolecules and may be perturbed in lysosomal storage disorders (LSDs). During …