Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

Long-term survival after kidney transplantation

S Hariharan, AK Israni… - New England Journal of …, 2021 - Mass Medical Soc
Long-Term Survival after Kidney Transplantation This review discusses demographics,
survival, and risks in kidney transplantation since the mid-1990s. It addresses postoperative …

Implantable bioelectronic systems for early detection of kidney transplant rejection

SR Madhvapathy, JJ Wang, H Wang, M Patel, A Chang… - Science, 2023 - science.org
Early-stage organ transplant rejection can be difficult to detect. Percutaneous biopsies occur
infrequently and are risky, and measuring biomarker levels in blood can lead to false …

Clinical translation of extracellular vesicles

A Ghodasara, A Raza, J Wolfram… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) occur in a variety of bodily fluids and have gained recent
attraction as natural materials due to their bioactive surfaces, internal cargo, and role in …

Exosomal RNAs: novel potential biomarkers for diseases—a review

J Wang, BL Yue, YZ Huang, XY Lan, WJ Liu… - International Journal of …, 2022 - mdpi.com
Exosomes are a subset of nano-sized extracellular vesicles originating from endosomes.
Exosomes mediate cell-to-cell communication with their cargos, which includes mRNAs …

Nephron mass determines the excretion rate of urinary extracellular vesicles

CJ Blijdorp, TA Hartjes, KY Wei… - Journal of …, 2022 - Wiley Online Library
Urinary extracellular vesicles (uEVs) are emerging as non‐invasive biomarkers for various
kidney diseases, but it is unknown how differences in nephron mass impact uEV excretion …

Urine stabilization and normalization strategies favor unbiased analysis of urinary EV content

R Vago, G Radano, D Zocco, N Zarovni - Scientific Reports, 2022 - nature.com
Urine features an ideal source of non-invasive diagnostic markers. Some intrinsic and
methodological issues still pose barriers to its full potential as liquid biopsy substrate. Unlike …

[HTML][HTML] Exosomes in urological diseases-biological functions and clinical applications

Q Song, H Yu, J Han, J Lv, Q Lv, H Yang - Cancer Letters, 2022 - Elsevier
Exosomes are extracellular vesicles with a variety of biological functions that exist in various
biological body fluids and exert their functions through proteins, nucleic acids, lipids, and …

Molecular immune monitoring in kidney transplant rejection: a state-of-the-art review

W Chancharoenthana, O Traitanon… - Frontiers in …, 2023 - frontiersin.org
Although current regimens of immunosuppressive drugs are effective in renal transplant
recipients, long-term renal allograft outcomes remain suboptimal. For many years, the …

Small extracellular vesicles in transplant rejection

JE Gołębiewska, A Wardowska, M Pietrowska… - Cells, 2021 - mdpi.com
Small extracellular vesicles (sEV), which are released to body fluids (eg, serum, urine) by all
types of human cells, may stimulate or inhibit the innate and adaptive immune response …