It is 20 years since the identification of PKD1, the major gene mutated in autosomal
dominant polycystic kidney disease (ADPKD), followed closely by the cloning of PKD2 …

Autosomal dominant polycystic kidney disease (ADPKD) is a progressive inherited disorder
in which renal tissue is gradually replaced with fluid-filled cysts, giving rise to chronic kidney …

WNT ligands induce Ca2+ signalling on target cells. PKD1 (polycystin 1) is considered an
orphan, atypical G-protein-coupled receptor complexed with TRPP2 (polycystin 2 or PKD2) …

A lack of sufficient oligodendrocyte myelination contributes to remyelination failure in
demyelinating disorders. miRNAs have been implicated in oligodendrogenesis; however …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD 1 or
PKD 2 gene, encoding the polycystic kidney disease protein polycystin‐1 and the transient …

Primary cilia contain specific receptors and channel proteins that sense the extracellular
milieu. Defective ciliary function causes ciliopathies such as autosomal dominant polycystic …

Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder
caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent …

Lymphatic vessels arise during development through sprouting of precursor cells from veins,
which is regulated by known signaling and transcriptional mechanisms. The ongoing …

Novel therapies in autosomal dominant polycystic kidney disease (ADPKD) signal the need
for markers of disease progression or response to therapy. This study aimed to identify …

Extracellular vesicles are a diverse group of particles that include exosomes, microvesicles,
and apoptotic bodies and are defined by size, composition, site of origin, and density. They …