Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities

Y Hu, Y Xing, H Yue, T Chen, Y Diao, W Wei… - Chemical Society …, 2023 - pubs.rsc.org
Ionic liquids (ILs), due to their inherent structural tunability, outstanding miscibility behavior,
and excellent electrochemical properties, have attracted significant research attention in the …

Green synthesis, biological and molecular docking of some novel sulfonamide thiadiazole derivatives as potential insecticidal against Spodoptera littoralis

AM El-Saghier, SS Enaili, AM Kadry, A Abdou… - Scientific Reports, 2023 - nature.com
Although crop plants provide the majority of human food, pests and insects frequently cause
huge economic losses. In order to develop innovative insecticidal compounds with low …

Structure and dynamics of pteridine reductase 1: the key phenomena relevant to enzyme function and drug design

J Panecka-Hofman, I Poehner - European Biophysics Journal, 2023 - Springer
Abstract Pteridine reductase 1 (PTR1) is a folate and pterin pathway enzyme unique for
pathogenic trypanosomatids. As a validated drug target, PTR1 has been the focus of recent …

An operationally simple, one‐pot, convenient synthesis, and in vitro anti‐inflammatory activity of some new spirotriazolotriazine derivatives

AM El‐Saghier, SS Enaili, A Abdou… - Journal of …, 2024 - Wiley Online Library
The wide biological actions of triazolotriazine hybrids, benzene‐sulfonamide derivatives,
exhibit a good chance of displaying in vitro anti‐inflammatory effects. An operationally …

Design, synthesis, in vitro and in silico studies of novel piperidine derived thiosemicarbazones as inhibitors of dihydrofolate reductase

H Aftab, S Ullah, A Khan, M Al-Rashida, T Islam… - Scientific Reports, 2024 - nature.com
Dihydrofolate reductase (DHFR), an essential enzyme in folate metabolism, presents a
promising target for drug development against various diseases, including cancer and …

Natural-product-inspired microwave-assisted synthesis of novel spirooxindoles as antileishmanial agents: synthesis, stereochemical assignment, bioevaluation, SAR …

NK Sahu, R Sharma, KP Suhas, J Joshi, K Prakash… - Molecules, 2023 - mdpi.com
Leishmaniasis is a neglected tropical disease, and there is an emerging need for the
development of effective drugs to treat it. To identify novel compounds with antileishmanial …

Synthesis of some new thiadiazole/thiadiazine derivatives as potent biologically active compounds

AM El-Saghier, A Abdul-Baset… - Sohag Journal of …, 2023 - sjsci.journals.ekb.eg
Due to the significant pharmacological and industrial value of 1, 3, 4-thiadiazole and 1, 3, 4-
thiadiazine, they are continuing to be of considerable interest to many researchers, therefore …

Thiadiazole/Thiadiazine Derivatives as Insecticidal Agent: Design, Synthesis, and Biological Assessment of 1, 3, 4-(Thiadiazine/Thiadiazole)-Benzenesulfonamide …

AM El-Saghier, SS Enaili, A Abdou… - Journal of Agricultural …, 2024 - ACS Publications
In keeping with our investigation, a simple and practical synthesis of novel heterocyclic
compounds with a sulfamoyl moiety that can be employed as insecticidal agents was …

Synthesis, docking and biological evaluation of purine-5-N-isosteresas anti-inflammatory agents

AM El-Saghier, SS Enaili, A Abdou, AM Hamed… - RSC …, 2024 - pubs.rsc.org
An operationally simple one-pot three-component and convenient synthesis method for a
series of diverse purine analogues of 5-amino-7-(substituted)-N-(4-sulfamoylphenyl)-4, 7 …

Synthesis, antileishmanial, antimalarial evaluation and molecular docking study of some hydrazine-coupled pyrazole derivatives

HG Berhe, YS Birhan, BY Beshay, HJ Habib, A Hymete… - BMC chemistry, 2024 - Springer
Pyrazole-bearing compounds are known for their diverse pharmacological effects including
potent antileishmanial and antimalarial activities. Herein, some hydrazine-coupled …