Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

In recent years, there has been a significant surge in reports on the health-promoting
benefits of winter cherry (Withania somnifera), also known as Ashwagandha. Its current …

In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating
cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide …

Autophagy, originally found in liver experiments, is a cellular process that degrades
damaged organelle or protein aggregation. This process frees cells from various stress …

Mitochondria form a complex, interconnected reticulum that is maintained through
coordination among biogenesis, dynamic fission, and fusion and mitophagy, which are …

AMP-activated protein kinase (AMPK) is a metabolic sensor in mammals that is activated
when ATP levels in the cell decrease. AMPK is a heterotrimeric protein that comprises 3 …

Doxorubicin is a commonly used chemotherapeutic agent for the treatment of a range of
cancers, but despite its success in improving cancer survival rates, doxorubicin is cardiotoxic …

The genome of pancreatic ductal adenocarcinoma (PDAC) frequently contains deletions of
tumour suppressor gene loci, most notably SMAD4, which is homozygously deleted in …

AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status
found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP …

We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the
pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP …