Challenges in pharmacological intervention in perilipins (PLINs) to modulate lipid droplet dynamics in obesity and cancer

V Bombarda-Rocha, D Silva, A Badr-Eddine… - Cancers, 2023 - mdpi.com
Simple Summary This review highlights the importance of perilipins in lipid metabolism and
their potential as therapeutic targets for lipid-associated diseases like cancer and obesity …

Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation

F Hao, M Tian, X Zhang, X Jin, Y Jiang… - Proceedings of the …, 2021 - National Acad Sciences
Inducible regulatory T (iTreg) cells play a crucial role in immune suppression and are
important for the maintenance of immune homeostasis. Mounting evidence has …

Monitoring and modelling the glutamine metabolic pathway: a review and future perspectives

Z Mirveis, O Howe, P Cahill, N Patil, HJ Byrne - Metabolomics, 2023 - Springer
Background Analysis of the glutamine metabolic pathway has taken a special place in
metabolomics research in recent years, given its important role in cell biosynthesis and …

Effective aspirin treatment of women at risk for preeclampsia delays the metabolic clock of gestation

X Li, A Milosavljevic, SH Elsea, CC Wang, F Scaglia… - …, 2021 - Am Heart Assoc
Preeclampsia, characterized by the onset of hypertension with significant proteinuria after 20
weeks' gestation, is one of the leading causes of maternal and perinatal morbidity and …

Optimized protocol for metabolomic and lipidomic profiling in formalin-fixed paraffin-embedded kidney tissue by LC-MS

SK Neef, S Winter, U Hofmann, TE Muerdter… - Analytica Chimica …, 2020 - Elsevier
Formalin-fixed and paraffin-embedded (FFPE) tissue represents a valuable resource to
examine cancer metabolic alterations and to identify potential markers of disease. Protocols …

Plasma metabolomics analysis of aspirin treatment and risk of colorectal adenomas

EL Barry, V Fedirko, Y Jin, K Liu, LA Mott… - Cancer Prevention …, 2022 - AACR
Despite substantial observational and experimental evidence that aspirin use can provide
protection against the development of colorectal neoplasia, our understanding of the …

Pharmacometabolomics: A new horizon in personalized medicine

AH Emwas, K Szczepski, RT McKay… - … and Applications in …, 2021 - books.google.com
Pharmacology is the predominant first-line treatment for most pathologies. However, various
factors, such as genetics, gender, diet, and health status, significantly influence the efficacy …

DDIT4 Downregulation by siRNA Approach Increases the Activity of Proteins Regulating Fatty Acid Metabolism upon Aspirin Treatment in Human Breast Cancer Cells

A Savukaitytė, A Bartnykaitė, J Bekampytė… - Current Issues in …, 2023 - mdpi.com
Repositioning of aspirin for a more effective breast cancer (BC) treatment requires
identification of predictive biomarkers. However, the molecular mechanism underlying the …

Genomic and epigenomic responses to aspirin in human colonic organoids

D Witonsky, MC Bielski, J Li… - Physiological …, 2023 - journals.physiology.org
Aspirin (ASA) is a proven chemoprotective agent for colorectal cancer, though mechanisms
underlying these effects are incompletely understood. Human organoids are an ideal system …