The SARS-CoV-2 pandemic urgently calls for the development of effective preventive tools.
COVID-19 hits greatly the elder and more fragile fraction of the population boosting the …

Abstract Purpose of Review Inflammatory signals have emerged as critical regulators of
hematopoietic stem cell (HSC) function. Specifically, HSCs are highly responsive to acute …

Covid-19 endangers lives, has disrupted normal life, changed the way medicine is practised
and is likely to alter our world for the foreseeable future. Almost two years on since the …

Abstract Purpose of Review The hematopoietic stem cell (HSC) compartment is the
cornerstone of a lifelong blood cell production but also contributes to the ability of the …

Background Giant cell arteritis (GCA) is a primary large-vessel vasculitis (LVV) of unknown
origin. Its management is a challenge due to the late onset of disease symptoms and …

Background With advancing age, the composition of leukocyte subpopulations in peripheral
blood is known to change, but how this change differs between men and women and how it …

Immunosenescence is the age-related changes in the immune system, namely,
progressively higher levels of circulating inflammatory markers, characteristics changes of …

This study addresses the potential to reverse age-associated morbidity by establishing
methods to restore the aged hematopoietic system. Parabiotic animal models indicated that …

To identify reliable biomarkers of age-related changes in chronic inflammation and
responsiveness to bacterial and viral challenges, we evaluated endogenous and ex vivo …

Clonal hematopoiesis of indeterminate potential (CHIP) is a recently identified process
where older patients accumulate distinct subclones defined by recurring somatic mutations …