Enzymes capable of assimilating fluorinated feedstocks are scarce. This situation poses a
challenge for the biosynthesis of fluorinated compounds used in pharmaceuticals …

Visible light-driven pyridoxal radical biocatalysis has emerged as a promising strategy for
the stereoselective synthesis of valuable noncanonical amino acids (ncAAs). Previously, the …

Amine dehydrogenases (AmDHs) are NAD (P) H‐dependent oxidoreductases that catalyze
the reductive amination between carbonyl compounds and ammonia as the amine donor …

Creating artificial enzymes by the genetic incorporation of noncanonical amino acids with
catalytic side chains would expand the enzyme chemistries that have not been discovered in …

2-Arylethylamines are presented in several natural bioactive compounds, as well as in
nitrogen-containing drugs. Their ability to surpass the blood–brain barrier makes this family …

Visible light-driven pyridoxal radical biocatalysis has emerged as a new strategy for the
stereoselective synthesis of valuable noncanonical amino acids in a protecting-group-free …

The Class I aldolases are known to construct C–C bonds with high enantioselectivity via
both natural enamine and promiscuous iminium ion intermediates. However, these enzymes …

Vicinal diamines are key motifs widely-found in many pharmaceuticals and biologically
active molecules. An appealing approach for synthesizing these molecules is the amination …

Heteroaromatic alkylations are indispensable reactions for synthesizing biologically active
molecules. The anti-Markovnikov hydroarylation of olefins using heteroaryl hal-ides …

Herein we describe a set of privileged and stereocomplementary ene-reductase enzymes
which, when induced by light and aided by an exogenous photocatalyst, catalyze the …