Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects
In the last decade, the development of messenger RNA (mRNA) therapeutics by lipid
nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of …
nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of …
The challenge and prospect of mRNA therapeutics landscape
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …
in the pharmaceutical industry because they can be used for precise and individualized …
Characterization of a messenger RNA polynucleotide vaccine vector
RM Conry, AF LoBuglio, M Wright, L Sumerel, MJ Pike… - Cancer research, 1995 - AACR
We have constructed mRNA transcripts encoding luciferase and human carcinoembryonic
antigen (CEA) which are capped, polyadenylated, and stabilized by human β-globin 5′ and …
antigen (CEA) which are capped, polyadenylated, and stabilized by human β-globin 5′ and …
Cationic lipids and methods for the delivery of therapeutic agents
J Heyes, L Palmer, M Maslowski… - US Patent 8,569,256, 2013 - Google Patents
0 [1*] N ([2*])([3*]) CC (COCCCCC/C= C\C/C= C\C/C= C\C [4*]) OCCCCC/C= C\C/C=
C\C/C= C\C [5*] Chemical compound [1*] N ([2*])([3*]) CC (COCCCCC/C= C\C/C= C\C/C …
C\C/C= C\C [5*] Chemical compound [1*] N ([2*])([3*]) CC (COCCCCC/C= C\C/C= C\C/C …
Lipid formulations for nucleic acid delivery
E Yaworski, K Lam, L Jeffs, L Palmer… - US Patent …, 2011 - Google Patents
The present invention provides novel, stable lipid particles comprising one or more active
agents or therapeutic agents, methods of making the lipid particles, and methods of deliv …
agents or therapeutic agents, methods of making the lipid particles, and methods of deliv …
Lipid encapsulated interfering RNA
I Maclachlan, LR Palmer, J Heyes - US Patent 7,799,565, 2010 - Google Patents
US7799565B2 - Lipid encapsulated interfering RNA - Google Patents US7799565B2 - Lipid
encapsulated interfering RNA - Google Patents Lipid encapsulated interfering RNA …
encapsulated interfering RNA - Google Patents Lipid encapsulated interfering RNA …
Cationic lipids and methods of use
J Heyes, I Maclachlan, LR Palmer - US Patent 7,745,651, 2010 - Google Patents
The present invention provides novel cationic lipids that have increased flexibility over
commonly used cationic lipids (such as DODAC and DODMA). When incorporated into lipid …
commonly used cationic lipids (such as DODAC and DODMA). When incorporated into lipid …
A nanostructured lipid carrier for delivery of a replicating viral RNA provides single, low-dose protection against Zika
JH Erasmus, AP Khandhar, J Guderian, B Granger… - Molecular Therapy, 2018 - cell.com
Since the first demonstration of in vivo gene expression from an injected RNA molecule
almost two decades ago, 1 the field of RNA-based therapeutics is now taking significant …
almost two decades ago, 1 the field of RNA-based therapeutics is now taking significant …
Modified siRNA molecules and uses thereof
I Maclachlan, A Judge - US Patent 8,101,741, 2012 - Google Patents
Targeted silencing of disease-associated genes by Syn thetic siRNA holds considerable
promise as a novel therapeu tic strategy. However, unmodified siRNA can be immuno …
promise as a novel therapeu tic strategy. However, unmodified siRNA can be immuno …
[图书][B] Liposomes in gene delivery
DD Lasic - 2019 - taylorfrancis.com
Many specialists are not familiar with both drug delivery and the molecular biology of DNA
vectors. Liposomes in Gene Delivery covers both-molecular biologists will gain a basic …
vectors. Liposomes in Gene Delivery covers both-molecular biologists will gain a basic …