A half-century of research on tuberculosis: Successes and challenges

BR Bloom - Journal of Experimental Medicine, 2023 - rupress.org
Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …

The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and …

K Dheda, T Gumbo, G Maartens, KE Dooley… - The Lancet …, 2019 - thelancet.com
Summary The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was
published in 2017, which comprehensively reviewed and provided recommendations on …

Transcriptomics for child and adolescent tuberculosis

M Kaforou, C Broderick, O Vito, M Levin… - Immunological …, 2022 - Wiley Online Library
Tuberculosis (TB) in humans is caused by Mycobacterium tuberculosis (Mtb). It is estimated
that 70 million children (< 15 years) are currently infected with Mtb, with 1.2 million each year …

Neutrophils in tuberculosis: Cell biology, cellular networking and multitasking in host defense

RR Borkute, S Woelke, G Pei, A Dorhoi - International journal of molecular …, 2021 - mdpi.com
Neutrophils readily infiltrate infection foci, phagocytose and usually destroy microbes. In
tuberculosis (TB), a chronic pulmonary infection caused by Mycobacterium tuberculosis …

Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections

M Moreno-Molina, N Shubladze, I Khurtsilava… - Nature …, 2021 - nature.com
Polyclonal infections occur when at least two unrelated strains of the same pathogen are
detected in an individual. This has been linked to worse clinical outcomes in tuberculosis, as …

[HTML][HTML] Use of digital technology to enhance tuberculosis control: scoping review

Y Lee, MC Raviglione, A Flahault - Journal of medical Internet research, 2020 - jmir.org
Background Tuberculosis (TB) is the leading cause of death from a single infectious agent,
with around 1.5 million deaths reported in 2018, and is a major contributor to suffering …

Immunometabolism during Mycobacterium tuberculosis infection

NC Howard, SA Khader - Trends in microbiology, 2020 - cell.com
Over a quarter of the world's population is infected with Mycobacterium tuberculosis (Mtb),
the causative agent of tuberculosis (TB). Approximately 3.4% of new and 18% of recurrent …

Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease

G Pollara, CT Turner, J Rosenheim… - Science translational …, 2021 - science.org
Host immune responses at the site of Mycobacterium tuberculosis infection can mediate
pathogenesis of tuberculosis (TB) and onward transmission of infection. We hypothesized …

Understanding the tuberculosis granuloma: the matrix revolutions

P Elkington, ME Polak, MT Reichmann… - Trends in Molecular …, 2022 - cell.com
Mycobacterium tuberculosis (Mtb) causes the human disease tuberculosis (TB) and remains
the top global infectious pandemic after coronavirus disease 2019 (COVID-19). Furthermore …

Mycobacterium tuberculosis Metabolism

GT Mashabela, TJ De Wet, DF Warner - Microbiology spectrum, 2019 - Am Soc Microbiol
Mycobacterium tuberculosis is the cause of tuberculosis (TB), a disease which continues to
overwhelm health systems in endemic regions despite the existence of effective combination …