[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
Spotlight on protein N-terminal acetylation
N-terminal acetylation (Nt-acetylation) is a widespread protein modification among
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases
Gene-disruptive mutations contribute to the biology of neurodevelopmental disorders
(NDDs), but most of the related pathogenic genes are not known. We sequenced 208 …
(NDDs), but most of the related pathogenic genes are not known. We sequenced 208 …
N-terminal cysteine acetylation and oxidation patterns may define protein stability
KC Heathcote, TP Keeley, M Myllykoski… - Nature …, 2024 - nature.com
Oxygen homeostasis is maintained in plants and animals by O2-sensing enzymes initiating
adaptive responses to low O2 (hypoxia). Recently, the O2-sensitive enzyme ADO was …
adaptive responses to low O2 (hypoxia). Recently, the O2-sensitive enzyme ADO was …
Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
First things first: vital protein marks by N-terminal acetyltransferases
N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
N‐terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects
The vast majority of eukaryotic proteins are N‐terminally modified by one or more
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
NATs at a glance
Most proteins receive an acetyl group at the N terminus while in their nascency as the result
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …
Cotranslational N-degron masking by acetylation promotes proteome stability in plants
E Linster, FL Forero Ruiz, P Miklankova… - Nature …, 2022 - nature.com
N-terminal protein acetylation (NTA) is a prevalent protein modification essential for viability
in animals and plants. The dominant executor of NTA is the ribosome tethered Nα …
in animals and plants. The dominant executor of NTA is the ribosome tethered Nα …
Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome
GJ Lyon, M Vedaie, T Beisheim, A Park… - European Journal of …, 2023 - nature.com
Abstract Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting
80% of cytosolic proteins in humans. The human essential gene, NAA10, encodes for the …
80% of cytosolic proteins in humans. The human essential gene, NAA10, encodes for the …