Vaccine adjuvants: mechanisms and platforms

T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

Photodynamic therapy: a brief history

D Kessel - Journal of clinical medicine, 2019 - mdpi.com
Photodynamic therapy (PDT) involves the selective sensitization of tissues to light. A major
advance in the field occurred when Thomas Dougherty at the Roswell Park Cancer Institute …

pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy

M Tang, B Chen, H Xia, M Pan, R Zhao, J Zhou… - Nature …, 2023 - nature.com
Abstract Tumour-associated macrophages (TAMs), as one of the most abundant tumour-
infiltrating immune cells, play a pivotal role in tumour antigen clearance and immune …

The course of immune stimulation by photodynamic therapy: bridging fundamentals of photochemically induced immunogenic cell death to the enrichment of T‐cell …

S Nath, G Obaid, T Hasan - Photochemistry and photobiology, 2019 - Wiley Online Library
Photodynamic therapy (PDT) is a potentially immunogenic and FDA‐approved antitumor
treatment modality that utilizes the spatiotemporal combination of a photosensitizer, light and …

Principles of immunotherapy: implications for treatment strategies in cancer and infectious diseases

K Naran, T Nundalall, S Chetty, S Barth - Frontiers in microbiology, 2018 - frontiersin.org
The advances in cancer biology and pathogenesis during the past two decades, have
resulted in immunotherapeutic strategies that have revolutionized the treatment of …

Photochemical internalization for intracellular drug delivery. From basic mechanisms to clinical research

W Jerjes, TA Theodossiou, H Hirschberg… - Journal of clinical …, 2020 - mdpi.com
Photochemical internalisation (PCI) is a unique intervention which involves the release of
endocytosed macromolecules into the cytoplasmic matrix. PCI is based on the use of …

Photochemical internalization: Light paves way for new cancer chemotherapies and vaccines

L Šošić, PK Selbo, ZK Kotkowska, TM Kündig… - Cancers, 2020 - mdpi.com
Photochemical internalization (PCI) is a further development of photodynamic therapy
(PDT). In this report, we describe PCI as a potential tool for cellular internalization of …

Vaccine-based immunotherapy for head and neck cancers

S Beyaert, JP Machiels, S Schmitz - Cancers, 2021 - mdpi.com
Simple Summary Therapeutic vaccines are given to patients with cancer, as opposed to
prophylactic vaccines given to a healthy population. The challenge for therapeutic …

Application of photodynamic therapy in immune-related diseases

D Yang, S Lei, K Pan, T Chen, J Lin, G Ni, J Liu… - Photodiagnosis and …, 2021 - Elsevier
Photodynamic therapy (PDT) is a therapeutic modality that utilizes photodamage caused by
photosensitizers and oxygen after exposure to a specific wavelength of light. Owing to its low …

Drug-loaded photosensitizer-chitosan nanoparticles for combinatorial chemo-and photodynamic-therapy of cancer

AD Pandya, A Øverbye, P Sahariah… - …, 2020 - ACS Publications
In this study we have developed biodegradable polymeric nanoparticles (NPs) containing
the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ). The NPs are based on chitosan …