Because cancers are caused by deregulation of hundreds of genes, an ideal anticancer
agent should target multiple gene products or signaling pathways simultaneously. Recently …

The brain is one of the first organs affected during sepsis development resulting in apoptosis
for a short-term and cognitive impairment for a long-term. Despite its importance, the …

The aim of the present study was to prepare curcumin nanoparticles (nanocurcumin) by a
sol-oil method to improve curcumin absorption and bioavailability, and to investigate the …

Caspase-8 plays an essential role in apoptosis triggered by death receptors. Through the
cleavage of Bid, a proapoptotic Bcl-2 member, it further activates the mitochondrial …

The discovery of the TRAIL protein and its death receptors DR4/5 changed the horizon of
cancer research because TRAIL specifically kills cancer cells. However, the validity of TRAIL …

In this study, we investigated the induction of oxidative stress and apoptosis in human
neuroblastoma cell line SH-SY5Y in response to alpha-cypermethrin (α-CYPER) exposure …

The cyclin-dependent kinase inhibitor p21 (p21WAF1/Cip1) is a multifunctional protein
known to promote cell cycle arrest and survival in response to p53-dependent and p53 …

Cancer is a mortality contributor worldwide, and breast cancer is the most common among
women. Despite the numerous breast cancer therapeutic strategies, they either have …

Background Primary traumatic mechanical injury to the spinal cord (SCI) causes the death of
a number of neurons that to date can neither be recovered nor regenerated. During the last …

We have compared cytoplasmic extracts from chicken DU249 cells at various stages along
the apoptotic pathway. Extracts from morphologically normal “committed stage” cells induce …